Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial
Diabetes mellitus characterized by hyperglycemia could increase oxidative stress and formation of advanced glycated end-products (AGEs), which contribute to diabetic complications. The purpose of this study was to assess the effect of pomegranate juice (PJ) containing natural antioxidant on lipid pe...
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| creator | Sohrab, Golbon Angoorani, Pooneh Tohidi, Maryam Tabibi, Hadi Kimiagar, Masoud Nasrollahzadeh, Javad |
| description | Diabetes mellitus characterized by hyperglycemia could increase oxidative stress and formation of advanced glycated end-products (AGEs), which contribute to diabetic complications. The purpose of this study was to assess the effect of pomegranate juice (PJ) containing natural antioxidant on lipid peroxidation and plasma AGEs in patients with type 2 diabetes (T2D).
In a randomized, double-blind, placebo-controlled trial, 44 patients (age range 56±6.8 years), T2D were randomly assigned to one of two groups: group A (PJ, n=22) and group B (Placebo, n=22). At the baseline and the end of 12-week intervention, biochemical markers including fasting plasma glucose, insulin, oxidative stress, and AGE markers including carboxy methyl lysine (CML) and pentosidine were assayed.
At baseline, there were no significant differences in plasma total antioxidant capacity (TAC) levels between the two groups, but malondialdehyde (MDA) decreased levels were significantly different (P |
| doi_str_mv | 10.3402/fnr.v59.28551 |
| format | Article |
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In a randomized, double-blind, placebo-controlled trial, 44 patients (age range 56±6.8 years), T2D were randomly assigned to one of two groups: group A (PJ, n=22) and group B (Placebo, n=22). At the baseline and the end of 12-week intervention, biochemical markers including fasting plasma glucose, insulin, oxidative stress, and AGE markers including carboxy methyl lysine (CML) and pentosidine were assayed.
At baseline, there were no significant differences in plasma total antioxidant capacity (TAC) levels between the two groups, but malondialdehyde (MDA) decreased levels were significantly different (P<0.001). After 12 weeks of intervention, TAC increased (P<0.05) and MDA decreased (P<0.01) in the PJ group when compared with the placebo group. However, no significant differences were observed in plasma concentration of CML and pentosidine between the two groups.
The study showed that PJ decreases lipid peroxidation. Therefore, PJ consumption may delay onset of T2D complications related to oxidative stress.</description><identifier>ISSN: 1654-6628</identifier><identifier>ISSN: 1654-661X</identifier><identifier>EISSN: 1654-661X</identifier><identifier>DOI: 10.3402/fnr.v59.28551</identifier><identifier>PMID: 26355954</identifier><language>eng</language><publisher>Sweden: Taylor & Francis</publisher><subject>Antioxidants ; Atherosclerosis ; Clinical trials ; Colleges & universities ; Compliance ; Diabetes ; Diabetic retinopathy ; Food science ; Gene expression ; health claims ; human nutrition ; Hyperglycemia ; metabolism ; Nutrition ; Original ; Oxidative stress ; Phytochemicals ; Plasma ; Proteins</subject><ispartof>Food & nutrition research, 2015-01, Vol.59 (1), p.28551-28551</ispartof><rights>2015 Golbon Sohrab et al. 2015</rights><rights>Copyright Co-Action Publishing 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-4aa506c814f4f54a2bf4c704a8f80d0bd46a721eaba165f15bd887c61425e7513</citedby><cites>FETCH-LOGICAL-c491t-4aa506c814f4f54a2bf4c704a8f80d0bd46a721eaba165f15bd887c61425e7513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565065/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565065/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,4125,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26355954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sohrab, Golbon</creatorcontrib><creatorcontrib>Angoorani, Pooneh</creatorcontrib><creatorcontrib>Tohidi, Maryam</creatorcontrib><creatorcontrib>Tabibi, Hadi</creatorcontrib><creatorcontrib>Kimiagar, Masoud</creatorcontrib><creatorcontrib>Nasrollahzadeh, Javad</creatorcontrib><title>Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial</title><title>Food & nutrition research</title><addtitle>Food Nutr Res</addtitle><description>Diabetes mellitus characterized by hyperglycemia could increase oxidative stress and formation of advanced glycated end-products (AGEs), which contribute to diabetic complications. The purpose of this study was to assess the effect of pomegranate juice (PJ) containing natural antioxidant on lipid peroxidation and plasma AGEs in patients with type 2 diabetes (T2D).
In a randomized, double-blind, placebo-controlled trial, 44 patients (age range 56±6.8 years), T2D were randomly assigned to one of two groups: group A (PJ, n=22) and group B (Placebo, n=22). At the baseline and the end of 12-week intervention, biochemical markers including fasting plasma glucose, insulin, oxidative stress, and AGE markers including carboxy methyl lysine (CML) and pentosidine were assayed.
At baseline, there were no significant differences in plasma total antioxidant capacity (TAC) levels between the two groups, but malondialdehyde (MDA) decreased levels were significantly different (P<0.001). After 12 weeks of intervention, TAC increased (P<0.05) and MDA decreased (P<0.01) in the PJ group when compared with the placebo group. However, no significant differences were observed in plasma concentration of CML and pentosidine between the two groups.
The study showed that PJ decreases lipid peroxidation. Therefore, PJ consumption may delay onset of T2D complications related to oxidative stress.</description><subject>Antioxidants</subject><subject>Atherosclerosis</subject><subject>Clinical trials</subject><subject>Colleges & universities</subject><subject>Compliance</subject><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Food science</subject><subject>Gene expression</subject><subject>health claims</subject><subject>human nutrition</subject><subject>Hyperglycemia</subject><subject>metabolism</subject><subject>Nutrition</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Phytochemicals</subject><subject>Plasma</subject><subject>Proteins</subject><issn>1654-6628</issn><issn>1654-661X</issn><issn>1654-661X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqVw5IoscSkSKXFiJ9kekFDFR6VK9AASN2tij3e9cuxgO1uW38cPw9stK4q42GP78Tvj8VsUz2l11rCqfqNdONvwxVndc04fFMe05axsW_rt4SGu-6PiSYzrqmqbqmePi6O6bThfcHZc_Lr2Iy4DOEhITq9nZyTsl_P4iqxnI5EolAEhYiTWTEaRCYP_YRQk491rMsyJrCAS5wlqjTIR78hkIY5AQG3ASVRkabcyZ1AEnSqn4NUsUyTGZWK2OboxaUXSdkJSE2VgwITxnADJlSg_mp_5pvLzYLEcrHGKyDzmSi1JwYB9WjzSYCM-u5tPiq8f3n-5-FReff54efHuqpRsQVPJAHjVyp4yzTRnUA-aya5i0Ou-UtWgWAtdTREGyJ3TlA-q7zvZUlZz7DhtTorLva7ysBZTMCOErfBgxO2GD0sBIRlpUXRt02kqGUfWMd3AoKCRemg4q0DxRZ-13u61pnkYUUl0KYC9J3r_xJmVWPqNYLzNr-BZ4PROIPjvM8YkRhMlWgsO_RwF7SjN2eqaZfTlP-jaz8HlVu2ovlt0Vb-rqNxTMvgYA-pDMbQSO6-J7DWRvSZuvZb5F3-_4ED_MVcG-j1gnPZhhBsfrBIJttYHnX9Wmiia_2v_BoV06EI</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Sohrab, Golbon</creator><creator>Angoorani, Pooneh</creator><creator>Tohidi, Maryam</creator><creator>Tabibi, Hadi</creator><creator>Kimiagar, Masoud</creator><creator>Nasrollahzadeh, Javad</creator><general>Taylor & Francis</general><general>Swedish Nutrition Foundation, SNF</general><general>Co-Action Publishing</general><general>Swedish Nutrition Foundation</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T7</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150101</creationdate><title>Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial</title><author>Sohrab, Golbon ; Angoorani, Pooneh ; Tohidi, Maryam ; Tabibi, Hadi ; Kimiagar, Masoud ; Nasrollahzadeh, Javad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-4aa506c814f4f54a2bf4c704a8f80d0bd46a721eaba165f15bd887c61425e7513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antioxidants</topic><topic>Atherosclerosis</topic><topic>Clinical trials</topic><topic>Colleges & universities</topic><topic>Compliance</topic><topic>Diabetes</topic><topic>Diabetic retinopathy</topic><topic>Food science</topic><topic>Gene expression</topic><topic>health claims</topic><topic>human nutrition</topic><topic>Hyperglycemia</topic><topic>metabolism</topic><topic>Nutrition</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Phytochemicals</topic><topic>Plasma</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sohrab, Golbon</creatorcontrib><creatorcontrib>Angoorani, Pooneh</creatorcontrib><creatorcontrib>Tohidi, Maryam</creatorcontrib><creatorcontrib>Tabibi, Hadi</creatorcontrib><creatorcontrib>Kimiagar, Masoud</creatorcontrib><creatorcontrib>Nasrollahzadeh, Javad</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Food & nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sohrab, Golbon</au><au>Angoorani, Pooneh</au><au>Tohidi, Maryam</au><au>Tabibi, Hadi</au><au>Kimiagar, Masoud</au><au>Nasrollahzadeh, Javad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial</atitle><jtitle>Food & nutrition research</jtitle><addtitle>Food Nutr Res</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>59</volume><issue>1</issue><spage>28551</spage><epage>28551</epage><pages>28551-28551</pages><issn>1654-6628</issn><issn>1654-661X</issn><eissn>1654-661X</eissn><abstract>Diabetes mellitus characterized by hyperglycemia could increase oxidative stress and formation of advanced glycated end-products (AGEs), which contribute to diabetic complications. The purpose of this study was to assess the effect of pomegranate juice (PJ) containing natural antioxidant on lipid peroxidation and plasma AGEs in patients with type 2 diabetes (T2D).
In a randomized, double-blind, placebo-controlled trial, 44 patients (age range 56±6.8 years), T2D were randomly assigned to one of two groups: group A (PJ, n=22) and group B (Placebo, n=22). At the baseline and the end of 12-week intervention, biochemical markers including fasting plasma glucose, insulin, oxidative stress, and AGE markers including carboxy methyl lysine (CML) and pentosidine were assayed.
At baseline, there were no significant differences in plasma total antioxidant capacity (TAC) levels between the two groups, but malondialdehyde (MDA) decreased levels were significantly different (P<0.001). After 12 weeks of intervention, TAC increased (P<0.05) and MDA decreased (P<0.01) in the PJ group when compared with the placebo group. However, no significant differences were observed in plasma concentration of CML and pentosidine between the two groups.
The study showed that PJ decreases lipid peroxidation. Therefore, PJ consumption may delay onset of T2D complications related to oxidative stress.</abstract><cop>Sweden</cop><pub>Taylor & Francis</pub><pmid>26355954</pmid><doi>10.3402/fnr.v59.28551</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Atherosclerosis Clinical trials Colleges & universities Compliance Diabetes Diabetic retinopathy Food science Gene expression health claims human nutrition Hyperglycemia metabolism Nutrition Original Oxidative stress Phytochemicals Plasma Proteins |
| title | Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial |
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