Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals

Alcoholism, or alcohol use disorder, is a major public health concern that is a considerable risk factor for morbidity and disability; therefore, effective treatments are urgently needed. Here, we demonstrated that the glucocorticoid receptor (GR) antagonist mifepristone reduces alcohol intake in al...

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Veröffentlicht in:	The Journal of clinical investigation 2015-08, Vol.125 (8), p.3193-3197
Hauptverfasser:	Vendruscolo, Leandro F, Estey, David, Goodell, Vivian, Macshane, Lauren G, Logrip, Marian L, Schlosburg, Joel E, McGinn, M Adrienne, Zamora-Martinez, Eva R, Belanoff, Joseph K, Hunt, Hazel J, Sanna, Pietro P, George, Olivier, Koob, George F, Edwards, Scott, Mason, Barbara J
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Administration, Oral Adult Alcohol Drinking - drug therapy Alcohol Drinking - physiopathology Alcohol use Alcoholism Alcoholism - drug therapy Alcoholism - physiopathology Animals Biomedical research Brain research Brief Report Confidentiality Drug dosages FDA approval Female Hormone Antagonists - administration & dosage Hormone Antagonists - adverse effects Hormone receptors Humans Hypotheses Laboratory animals Male Mifepristone Mifepristone - administration & dosage Mifepristone - adverse effects Multivariate analysis Phosphorylation Rats Receptors, Glucocorticoid - antagonists & inhibitors Rodents
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