Transcription factor ISL1 is essential for pacemaker development and function

The sinoatrial node (SAN) maintains a rhythmic heartbeat; therefore, a better understanding of factors that drive SAN development and function is crucial to generation of potential therapies, such as biological pacemakers, for sinus arrhythmias. Here, we determined that the LIM homeodomain transcrip...

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Veröffentlicht in:	The Journal of clinical investigation 2015-08, Vol.125 (8), p.3256-3268
Hauptverfasser:	Liang, Xingqun, Zhang, Qingquan, Cattaneo, Paola, Zhuang, Shaowei, Gong, Xiaohui, Spann, Nathanael J, Jiang, Cizhong, Cao, Xinkai, Zhao, Xiaodong, Zhang, Xiaoli, Bu, Lei, Wang, Gang, Chen, H S Vincent, Zhuang, Tao, Yan, Jie, Geng, Peng, Luo, Lina, Banerjee, Indroneal, Chen, Yihan, Glass, Christopher K, Zambon, Alexander C, Chen, Ju, Sun, Yunfu, Evans, Sylvia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Ankyrins - genetics Ankyrins - metabolism Arrhythmia Biomedical research Cardiac arrhythmia Cardiomyocytes Cell Proliferation - physiology Cell Survival Chromatin - genetics Chromatin - metabolism Deoxyribonucleic acid DNA Gene Deletion Gene expression Gene Expression Regulation, Developmental - physiology Genetic aspects Genomes Heart LIM-Homeodomain Proteins - genetics LIM-Homeodomain Proteins - metabolism Mice Mice, Transgenic Myocardial Contraction - physiology Protein Binding Risk factors Sick Sinus Syndrome - embryology Sick Sinus Syndrome - genetics Sick Sinus Syndrome - pathology Sinoatrial node Sinoatrial Node - cytology Sinoatrial Node - embryology Sinuses Studies T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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