Engineering the gut microbiota to treat hyperammonemia

Increasing evidence indicates that the gut microbiota can be altered to ameliorate or prevent disease states, and engineering the gut microbiota to therapeutically modulate host metabolism is an emerging goal of microbiome research. In the intestine, bacterial urease converts host-derived urea to am...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2015-07, Vol.125 (7), p.2841-2850
Hauptverfasser:	Shen, Ting-Chin David, Albenberg, Lindsey, Bittinger, Kyle, Chehoud, Christel, Chen, Ying-Yu, Judge, Colleen A, Chau, Lillian, Ni, Josephine, Sheng, Michael, Lin, Andrew, Wilkins, Benjamin J, Buza, Elizabeth L, Lewis, James D, Daikhin, Yevgeny, Nissim, Ilana, Yudkoff, Marc, Bushman, Frederic D, Wu, Gary D
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonia - metabolism Animals Bacteria Bacteria - enzymology Bacteria - genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioengineering Biological Therapy - methods Biomedical research Chemical and Drug Induced Liver Injury - therapy Deoxyribonucleic acid Digestive System - metabolism Digestive System - microbiology Disease Models, Animal DNA Feces - microbiology Female Genes, Bacterial Genomes Hyperammonemia - metabolism Hyperammonemia - microbiology Hyperammonemia - therapy Liver cirrhosis Liver diseases Male Metabolism Mice Mice, Inbred C57BL Mice, SCID Microbiota - physiology Mortality Probiotics Studies Time Factors Urease - genetics Urease - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!