Mature T cell responses are controlled by microRNA-142

T cell proliferation is critical for immune responses; however, the molecular mechanisms that mediate the proliferative response are poorly understood. MicroRNAs (miRs) regulate various molecular processes, including development and function of the immune system. Here, utilizing multiple complementa...

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Veröffentlicht in:	The Journal of clinical investigation 2015-07, Vol.125 (7), p.2825-2840
Hauptverfasser:	Sun, Yaping, Oravecz-Wilson, Katherine, Mathewson, Nathan, Wang, Ying, McEachin, Richard, Liu, Chen, Toubai, Tomomi, Wu, Julia, Rossi, Corinne, Braun, Thomas, Saunders, Thomas, Reddy, Pavan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals Apoptosis Biomedical research Bone Marrow Transplantation - adverse effects Cell Cycle - genetics Cell Differentiation Cell Proliferation Cytokines - metabolism E2F7 Transcription Factor - genetics Gene expression Genomes Graft vs Host Disease - genetics Graft vs Host Disease - immunology Immune system In Vitro Techniques Infections Laboratory animals Lymphocytes Methods Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout MicroRNAs - genetics MicroRNAs - immunology Milk Repressor Proteins - genetics Rodents Studies T-Lymphocytes - cytology T-Lymphocytes - immunology Up-Regulation
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