ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, protects transformed cells against anoikis - a speci...

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Veröffentlicht in:	The Journal of clinical investigation 2015-07, Vol.125 (7), p.2592-2592
Hauptverfasser:	Dey, Souvik, Sayers, Carly M, Verginadis, Ioannis I, Lehman, Stacey L, Cheng, Yi, Cerniglia, George J, Tuttle, Stephen W, Feldman, Michael D, Zhang, Paul J L, Fuchs, Serge Y, Diehl, J Alan, Koumenis, Constantinos
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 - antagonists & inhibitors Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Adenocarcinoma - enzymology Adenocarcinoma - genetics Adenocarcinoma of Lung Animals Anoikis - genetics Anoikis - physiology Biomedical research Cancer Cell Line, Tumor Cell Movement Colleges & universities Enzyme Induction Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Glioblastoma - enzymology Glioblastoma - genetics Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - genetics Heterografts Humans Hypoxia Kinases Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Lungs Membrane Proteins - biosynthesis Membrane Proteins - genetics Metastasis Mice Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasm Metastasis - physiopathology NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress Phosphorylation Reactive Oxygen Species - metabolism Rodents Stress response Transcription factors Tumors Unfolded Protein Response
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