STAT1 modification improves therapeutic effects of interferons on lung cancer cells

Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer. However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it difficult to achieve sustained therapeutic levels especially in solid tumors. Signal Transduce...

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Veröffentlicht in:	Journal of translational medicine 2015-09, Vol.13 (1), p.293-293, Article 293
Hauptverfasser:	Chen, Junjie, Zhao, Jialu, Chen, Lefu, Dong, Nian, Ying, Zhaojian, Cai, Zhenzhen, Ji, Dongxiang, Zhang, Yong, Dong, Li, Li, Yuping, Jiang, Lei, Holtzman, Michael J, Chen, Chengshui
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - therapeutic use Apoptosis beta Catenin - metabolism Biological response modifiers Cancer Cancer cells Care and treatment Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Complications and side effects Development and progression Fibronectins Fibronectins - metabolism Fluorescence Gene Expression Regulation, Neoplastic Green Fluorescent Proteins - chemistry Health aspects HEK293 Cells Humans Interferon Interferon-beta - pharmacology Interferon-gamma - pharmacology Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Neoplasm Invasiveness Neoplasm Metastasis Patient outcomes Phosphorylation Prevention STAT1 Transcription Factor - chemistry STAT1 Transcription Factor - genetics
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