Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions

CTCF and BORIS (CTCFL), two paralogous mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutually exclusive manner in DNA binding and transcriptional regulation. Here we show that these two proteins co-occupy a specific subset of regulatory elements consis...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genome Biology 2015-08, Vol.16 (1), p.161-161, Article 161
Hauptverfasser:	Pugacheva, Elena M, Rivero-Hinojosa, Samuel, Espinoza, Celso A, Méndez-Catalá, Claudia Fabiola, Kang, Sungyun, Suzuki, Teruhiko, Kosaka-Suzuki, Natsuki, Robinson, Susan, Nagarajan, Vijayaraj, Ye, Zhen, Boukaba, Abdelhalim, Rasko, John E J, Strunnikov, Alexander V, Loukinov, Dmitri, Ren, Bing, Lobanenkov, Victor V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Bioinformatics Biotechnology industry Cancer CCCTC-Binding Factor Cell Line Chromatin Chromatin - chemistry Comparative analysis Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA-Binding Proteins - metabolism Ectopic expression Enhancer Elements, Genetic Enhancers Gene expression Gene regulation Genes Genetic transcription Genome Genomes Genomics Germ cells Humans K562 Cells Male Mice Neoplasms - genetics Nucleotide Motifs Promoter Regions, Genetic Protamine Protein Binding Proteins Regulatory sequences Repressor Proteins - metabolism Sperm Spermatids - metabolism Spermatozoa - metabolism Stem cells Transcription Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!