Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets
The aim of current study was to explore the influence of three commonly used polymers, that is, cellulosics and noncellulosics, for example, Methocel K4M, Kollidon VA/64, and Soluplus, on the phase disproportionation and drug release profile of carbamazepine-succinic acid (CBZ-SUC) cocrystal at vary...
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| Veröffentlicht in: | BioMed research international 2015-01, Vol.2015 (2015), p.1-10 |
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| creator | Mahmood, Qaisar Murtaza, Ghulam Ullah, Hanif Ullah, Majeed Hussain, Izhar |
| description | The aim of current study was to explore the influence of three commonly used polymers, that is, cellulosics and noncellulosics, for example, Methocel K4M, Kollidon VA/64, and Soluplus, on the phase disproportionation and drug release profile of carbamazepine-succinic acid (CBZ-SUC) cocrystal at varying drug to polymer ratios (1 : 1 to 1 : 0.25) in matrix tablets. The polymorphic phase disproportionation during in-depth dissolution studies of CBZ-SUC cocrystals and its crystalline properties were scrutinized by X-ray powder diffractrometry and Raman spectroscopy. The percent drug release from HPMC formulations (CSH) showed inverse relation with the concentration of polymer; that is, drug release increased with decrease in polymer concentration. On contrary, direct relation was observed between percent drug release and polymer concentrations of Kollidon VA 64/Soluplus (CSK, CSS). At similar polymer concentration, drug release from pure carbamazepine was slightly lower with HPMC formulations than that of cocrystal; however, opposite trend in release rate was observed with Kollidon VA/64 and Soluplus. The significant increase in dissolution rate of cocrystal occurred with Kollidon VA/64 and Soluplus at higher polymer concentration. Moreover, no phase change took place in Methocel and Kollidon formulations. No tablet residue was left for Soluplus formulation so the impact of polymer on cocrystal integrity cannot be predicted. |
| doi_str_mv | 10.1155/2015/870656 |
| format | Article |
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The polymorphic phase disproportionation during in-depth dissolution studies of CBZ-SUC cocrystals and its crystalline properties were scrutinized by X-ray powder diffractrometry and Raman spectroscopy. The percent drug release from HPMC formulations (CSH) showed inverse relation with the concentration of polymer; that is, drug release increased with decrease in polymer concentration. On contrary, direct relation was observed between percent drug release and polymer concentrations of Kollidon VA 64/Soluplus (CSK, CSS). At similar polymer concentration, drug release from pure carbamazepine was slightly lower with HPMC formulations than that of cocrystal; however, opposite trend in release rate was observed with Kollidon VA/64 and Soluplus. The significant increase in dissolution rate of cocrystal occurred with Kollidon VA/64 and Soluplus at higher polymer concentration. Moreover, no phase change took place in Methocel and Kollidon formulations. No tablet residue was left for Soluplus formulation so the impact of polymer on cocrystal integrity cannot be predicted.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/870656</identifier><identifier>PMID: 26380301</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Aqueous solutions ; Bioavailability ; Biopolymers ; Carbamazepine ; Carbamazepine - chemistry ; Carbamazepine - pharmacology ; Chemical properties ; Chemistry, Pharmaceutical ; Crystallization ; Dissolution ; Dissolution (Chemistry) ; Drug Liberation ; Drugs ; Humans ; Hypromellose Derivatives - chemistry ; Hypromellose Derivatives - pharmacology ; Identification and classification ; Information technology ; Kinetics ; Niacinamide - chemistry ; Niacinamide - pharmacology ; Observations ; Pharmaceuticals ; Phase transformations (Statistical physics) ; Phase transitions ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacology ; Polymers ; Polymers - chemistry ; Polymers - pharmacology ; Polyvinyls - chemistry ; Polyvinyls - pharmacology ; Povidone - chemistry ; Povidone - pharmacology ; Solubility ; Spectrum analysis ; Studies ; Succinic acid ; Succinic Acid - chemistry ; Succinic Acid - pharmacology ; Tablets</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-10</ispartof><rights>Copyright © 2015 Majeed Ullah et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Majeed Ullah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Majeed Ullah et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-ce36dbb85ed6b07477d8d4170c9b37b5c9b34cf8d01b24d1c4d3825819f99b703</citedby><cites>FETCH-LOGICAL-c528t-ce36dbb85ed6b07477d8d4170c9b37b5c9b34cf8d01b24d1c4d3825819f99b703</cites><orcidid>0000-0001-5649-5768</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561304/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561304/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26380301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Odeku, Oluwatoyin A.</contributor><creatorcontrib>Mahmood, Qaisar</creatorcontrib><creatorcontrib>Murtaza, Ghulam</creatorcontrib><creatorcontrib>Ullah, Hanif</creatorcontrib><creatorcontrib>Ullah, Majeed</creatorcontrib><creatorcontrib>Hussain, Izhar</creatorcontrib><title>Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The aim of current study was to explore the influence of three commonly used polymers, that is, cellulosics and noncellulosics, for example, Methocel K4M, Kollidon VA/64, and Soluplus, on the phase disproportionation and drug release profile of carbamazepine-succinic acid (CBZ-SUC) cocrystal at varying drug to polymer ratios (1 : 1 to 1 : 0.25) in matrix tablets. The polymorphic phase disproportionation during in-depth dissolution studies of CBZ-SUC cocrystals and its crystalline properties were scrutinized by X-ray powder diffractrometry and Raman spectroscopy. The percent drug release from HPMC formulations (CSH) showed inverse relation with the concentration of polymer; that is, drug release increased with decrease in polymer concentration. On contrary, direct relation was observed between percent drug release and polymer concentrations of Kollidon VA 64/Soluplus (CSK, CSS). At similar polymer concentration, drug release from pure carbamazepine was slightly lower with HPMC formulations than that of cocrystal; however, opposite trend in release rate was observed with Kollidon VA/64 and Soluplus. The significant increase in dissolution rate of cocrystal occurred with Kollidon VA/64 and Soluplus at higher polymer concentration. Moreover, no phase change took place in Methocel and Kollidon formulations. No tablet residue was left for Soluplus formulation so the impact of polymer on cocrystal integrity cannot be predicted.</description><subject>Analysis</subject><subject>Aqueous solutions</subject><subject>Bioavailability</subject><subject>Biopolymers</subject><subject>Carbamazepine</subject><subject>Carbamazepine - chemistry</subject><subject>Carbamazepine - pharmacology</subject><subject>Chemical properties</subject><subject>Chemistry, Pharmaceutical</subject><subject>Crystallization</subject><subject>Dissolution</subject><subject>Dissolution (Chemistry)</subject><subject>Drug Liberation</subject><subject>Drugs</subject><subject>Humans</subject><subject>Hypromellose Derivatives - chemistry</subject><subject>Hypromellose Derivatives - pharmacology</subject><subject>Identification and classification</subject><subject>Information technology</subject><subject>Kinetics</subject><subject>Niacinamide - chemistry</subject><subject>Niacinamide - pharmacology</subject><subject>Observations</subject><subject>Pharmaceuticals</subject><subject>Phase transformations (Statistical physics)</subject><subject>Phase transitions</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Polymers</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>Polyvinyls - chemistry</subject><subject>Polyvinyls - pharmacology</subject><subject>Povidone - chemistry</subject><subject>Povidone - pharmacology</subject><subject>Solubility</subject><subject>Spectrum analysis</subject><subject>Studies</subject><subject>Succinic acid</subject><subject>Succinic Acid - chemistry</subject><subject>Succinic Acid - pharmacology</subject><subject>Tablets</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkktv1DAUhSMEolXpij2yxAaBQv2K42yQhqFApSIqUdhafqXjyrEHOxkYfgE_G4cpQ2FVb64tfz669_hU1WMEXyLUNCcYouaEt5A17F51iAmiNUMU3d_vCTmojnO-hmVxxGDHHlYHmBEOCUSH1c_TjfSTHF0MIPbgLPR-skHb-fBFJhenDC6i3w42ZVCYNy7n6KffvAwGXKxktuC1XcmNi2l-tZRJyUH-sGsXbP1p0toFp8FCOwOWUadtHqUHLoAPckzuO7iUytsxP6oe9NJne3xTj6rPb08vl-_r84_vzpaL81o3mI-1toQZpXhjDVOwpW1ruKGohbpTpFXNXKjuuYFIYWqQpoZw3HDU9V2nWkiOqlc73fWkBmu0DWOSXqyTG2Taiiid-PcmuJW4ihtBm2ImpEXg2Y1Ail8nm0cxuKyt9zLY4pZALcaIUdyxO6CIdLTDtCvo0__Q6zilUJwoVPm0jmBK_1JX0lvhQh9Li3oWFQtahmSE8XnEFztKp5hzsv1-OgTFnBoxp0bsUlPoJ7cN2bN_MlKA5ztg5YKR39zd1GxBbC9vwU0LOSG_AOS80w4</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Mahmood, Qaisar</creator><creator>Murtaza, Ghulam</creator><creator>Ullah, Hanif</creator><creator>Ullah, Majeed</creator><creator>Hussain, Izhar</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5649-5768</orcidid></search><sort><creationdate>20150101</creationdate><title>Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets</title><author>Mahmood, Qaisar ; Murtaza, Ghulam ; Ullah, Hanif ; Ullah, Majeed ; Hussain, Izhar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-ce36dbb85ed6b07477d8d4170c9b37b5c9b34cf8d01b24d1c4d3825819f99b703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Aqueous solutions</topic><topic>Bioavailability</topic><topic>Biopolymers</topic><topic>Carbamazepine</topic><topic>Carbamazepine - 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chemistry</topic><topic>Povidone - pharmacology</topic><topic>Solubility</topic><topic>Spectrum analysis</topic><topic>Studies</topic><topic>Succinic acid</topic><topic>Succinic Acid - chemistry</topic><topic>Succinic Acid - pharmacology</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahmood, Qaisar</creatorcontrib><creatorcontrib>Murtaza, Ghulam</creatorcontrib><creatorcontrib>Ullah, Hanif</creatorcontrib><creatorcontrib>Ullah, Majeed</creatorcontrib><creatorcontrib>Hussain, Izhar</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmood, Qaisar</au><au>Murtaza, Ghulam</au><au>Ullah, Hanif</au><au>Ullah, Majeed</au><au>Hussain, Izhar</au><au>Odeku, Oluwatoyin A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>2015</volume><issue>2015</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The aim of current study was to explore the influence of three commonly used polymers, that is, cellulosics and noncellulosics, for example, Methocel K4M, Kollidon VA/64, and Soluplus, on the phase disproportionation and drug release profile of carbamazepine-succinic acid (CBZ-SUC) cocrystal at varying drug to polymer ratios (1 : 1 to 1 : 0.25) in matrix tablets. The polymorphic phase disproportionation during in-depth dissolution studies of CBZ-SUC cocrystals and its crystalline properties were scrutinized by X-ray powder diffractrometry and Raman spectroscopy. The percent drug release from HPMC formulations (CSH) showed inverse relation with the concentration of polymer; that is, drug release increased with decrease in polymer concentration. On contrary, direct relation was observed between percent drug release and polymer concentrations of Kollidon VA 64/Soluplus (CSK, CSS). At similar polymer concentration, drug release from pure carbamazepine was slightly lower with HPMC formulations than that of cocrystal; however, opposite trend in release rate was observed with Kollidon VA/64 and Soluplus. The significant increase in dissolution rate of cocrystal occurred with Kollidon VA/64 and Soluplus at higher polymer concentration. Moreover, no phase change took place in Methocel and Kollidon formulations. No tablet residue was left for Soluplus formulation so the impact of polymer on cocrystal integrity cannot be predicted.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26380301</pmid><doi>10.1155/2015/870656</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5649-5768</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Aqueous solutions Bioavailability Biopolymers Carbamazepine Carbamazepine - chemistry Carbamazepine - pharmacology Chemical properties Chemistry, Pharmaceutical Crystallization Dissolution Dissolution (Chemistry) Drug Liberation Drugs Humans Hypromellose Derivatives - chemistry Hypromellose Derivatives - pharmacology Identification and classification Information technology Kinetics Niacinamide - chemistry Niacinamide - pharmacology Observations Pharmaceuticals Phase transformations (Statistical physics) Phase transitions Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polymers Polymers - chemistry Polymers - pharmacology Polyvinyls - chemistry Polyvinyls - pharmacology Povidone - chemistry Povidone - pharmacology Solubility Spectrum analysis Studies Succinic acid Succinic Acid - chemistry Succinic Acid - pharmacology Tablets |
| title | Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets |
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