CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance

Tumor adaptive resistance to therapeutic radiation remains a barrier for further improvement of local cancer control. SIRT3, a member of the sirtuin family of NAD(+)-dependent protein deacetylases in mitochondria, promotes metabolic homeostasis through regulation of mitochondrial protein deacetylati...

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Veröffentlicht in:	Molecular cancer therapeutics 2015-09, Vol.14 (9), p.2090-2102
Hauptverfasser:	Liu, Rui, Fan, Ming, Candas, Demet, Qin, Lili, Zhang, Xiaodi, Eldridge, Angela, Zou, June X, Zhang, Tieqiao, Juma, Shuaib, Jin, Cuihong, Li, Robert F, Perks, Julian, Sun, Lun-Quan, Vaughan, Andrew T M, Hai, Chun-Xu, Gius, David R, Li, Jian Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals CDC2 Protein Kinase Cell Line, Tumor Cyclin-Dependent Kinases - metabolism Disease Models, Animal Enzyme Activation Gene Expression Regulation, Neoplastic - radiation effects Humans Mitochondria - metabolism Mitochondria - radiation effects Mitochondrial Proteins - metabolism Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplasms - radiotherapy NF-kappa B - metabolism Phosphorylation Radiation Tolerance - genetics Sirtuin 3 - genetics Sirtuin 3 - metabolism Transcription, Genetic Transcriptional Activation
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