Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer

Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cel...

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Veröffentlicht in:	Cell stem cell 2015-09, Vol.17 (3), p.260-271
Hauptverfasser:	Brooks, Michael D., Burness, Monika L., Wicha, Max S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - classification Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinogenesis - pathology Clinical Trials as Topic Female Humans Mutation - genetics Neoplastic Stem Cells - pathology Tumor Microenvironment
Online-Zugang:	Volltext
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