Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer
Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cel...
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| Veröffentlicht in: | Cell stem cell 2015-09, Vol.17 (3), p.260-271 |
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| creator | Brooks, Michael D. Burness, Monika L. Wicha, Max S. |
| description | Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cell self-renewal and differentiation. Many, if not most, tumors display similar hierarchal organization, at the apex of which are “stem-like cells” that drive tumor growth, mediate metastasis, and contribute to treatment resistance. Using breast cancer as a model, we discuss how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies.
Max Wicha and colleagues use breast cancer as a model to highlight how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies. |
| doi_str_mv | 10.1016/j.stem.2015.08.014 |
| format | Article |
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Max Wicha and colleagues use breast cancer as a model to highlight how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies.</description><subject>Breast Neoplasms - classification</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Carcinogenesis - pathology</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>Humans</subject><subject>Mutation - genetics</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Tumor Microenvironment</subject><issn>1934-5909</issn><issn>1875-9777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1r3DAQFaUhX80f6KH42IudkSxZEpRCuzQfEEgp6VnI8myixba2khzIv6-WTUNy6WlmmPeeNO8R8pFCQ4F255smZZwaBlQ0oBqg_B05pkqKWksp35det7wWGvQROUlpAyAkBXlIjljXchCsOya_7h4w2i0u2bvqetqO3tnsw5yqsK5WOI7LaGN1hRljuMcZfX6q7DxUP0ebCmU3-rn6HrGM1crODuMHcrC2Y8Kz53pKfl_8uFtd1Te3l9erbze1E4zmWrUDbYEq7GmHzPXMaa6c5dBJoSSwXnCphWB9Z60Y0A22VZJT1jrQA_SyPSVf97rbpZ9wcDjnaEezjX6y8ckE683bzewfzH14NFx0oDgUgc_PAjH8WTBlM_nkys12xrAkQyVoCVLotkDZHupiSCni-uUZCmYXhtmYXRhmF4YBZUoYhfTp9QdfKP_cL4AvewAWmx49RpOcx-Lh4CO6bIbg_6f_F5DhnHQ</recordid><startdate>20150903</startdate><enddate>20150903</enddate><creator>Brooks, Michael D.</creator><creator>Burness, Monika L.</creator><creator>Wicha, Max S.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150903</creationdate><title>Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer</title><author>Brooks, Michael D. ; Burness, Monika L. ; Wicha, Max S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-83d13018eb16e2cb2c948ca406758702b5479552b6aa5decda3874123c09d0b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Breast Neoplasms - classification</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Carcinogenesis - pathology</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>Humans</topic><topic>Mutation - genetics</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brooks, Michael D.</creatorcontrib><creatorcontrib>Burness, Monika L.</creatorcontrib><creatorcontrib>Wicha, Max S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell stem cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brooks, Michael D.</au><au>Burness, Monika L.</au><au>Wicha, Max S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer</atitle><jtitle>Cell stem cell</jtitle><addtitle>Cell Stem Cell</addtitle><date>2015-09-03</date><risdate>2015</risdate><volume>17</volume><issue>3</issue><spage>260</spage><epage>271</epage><pages>260-271</pages><issn>1934-5909</issn><eissn>1875-9777</eissn><abstract>Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cell self-renewal and differentiation. Many, if not most, tumors display similar hierarchal organization, at the apex of which are “stem-like cells” that drive tumor growth, mediate metastasis, and contribute to treatment resistance. Using breast cancer as a model, we discuss how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies.
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Breast Neoplasms - classification Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinogenesis - pathology Clinical Trials as Topic Female Humans Mutation - genetics Neoplastic Stem Cells - pathology Tumor Microenvironment |
| title | Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer |
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