Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

Dissemination of tumor cells is an essential step in metastasis. Direct contact between a macrophage, mammalian-enabled (MENA)-overexpressing tumor cell, and endothelial cell [Tumor MicroEnvironment of Metastasis (TMEM)] correlates with metastasis in breast cancer patients. Here we show, using intra...

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Veröffentlicht in:	Cancer discovery 2015-09, Vol.5 (9), p.932-943
Hauptverfasser:	Harney, Allison S, Arwert, Esther N, Entenberg, David, Wang, Yarong, Guo, Peng, Qian, Bin-Zhi, Oktay, Maja H, Pollard, Jeffrey W, Jones, Joan G, Condeelis, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Capillary Permeability - drug effects Cell Movement - drug effects Female Humans Immunophenotyping Macrophages - metabolism Mice Mice, Transgenic Models, Biological Molecular Imaging Neovascularization, Pathologic Phenotype Receptor, TIE-2 - metabolism Signal Transduction - drug effects Time-Lapse Imaging Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - pharmacology
Online-Zugang:	Volltext
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