Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes After Cardiac Arrest and Targeted Temperature Management
Background Brain recovery after cardiac arrest (CA) is sensitive to temperature. Yet the effect of temperature management on different EEG frequency bands has not been elucidated. A novel quantitative EEG algorithm, sub-band information quantity (SIQ), was applied to evaluate EEG recovery and outcom...
Gespeichert in:
| Veröffentlicht in: | Neurocritical care 2015-10, Vol.23 (2), p.262-273 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 273 |
|---|---|
| container_issue | 2 |
| container_start_page | 262 |
| container_title | Neurocritical care |
| container_volume | 23 |
| creator | Deng, Ruoxian Koenig, Matthew A. Young, Leanne Moon Jia, Xiaofeng |
| description | Background
Brain recovery after cardiac arrest (CA) is sensitive to temperature. Yet the effect of temperature management on different EEG frequency bands has not been elucidated. A novel quantitative EEG algorithm, sub-band information quantity (SIQ), was applied to evaluate EEG recovery and outcomes after CA.
Methods
Twenty-four Wistar rats undergoing 7-min CA were randomly assigned to immediate hypothermia (32–34 °C), normothermia (36.5–37.5 °C), or hyperthermia (38.5–39.5 °C) (
n
= 8). EEG was recorded continuously for the first 8 h and then for serial 30-min epochs daily. The neurologic deficit score (NDS) at 72-h was the primary functional outcome. Another four rats without brain injury were added as a control.
Results
Better recovery of gamma-band SIQ was found in the hypothermia group (0.60 ± 0.03) compared with the normothermia group (0.40 ± 0.03) (
p
|
| doi_str_mv | 10.1007/s12028-015-0157-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4560606</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1709710666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-53dd7e414101068ba56682cbbd61fc4beb2577f48dc5d2ce088ffd3c29ecd3143</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhhtR3HX1B3iRgBcvrUk6H90XYRxmR2FlEcZzqE6qZ7P2x5ikV_bgf980s64fIKFIQT31VhVvUbxk9C2jVL-LjFNel5TJJXTJHxWnTEpV0kaxx0suWKmaqjopnsV4TSnXjZZPixOuWEUFlafFzw2E_pZ8mWFMPkHyN0i2MAxQfoDRkc1mSz5D-IaB-EhWMU7WQ0JHfvh0RS7nZKcBc6FLmVhDcB4sWYWAMZGlfwdhjwu_w-GAAdIcMAuOsMcBx_S8eNJBH_HF_X9WfD3f7NYfy4vL7af16qK0UtBUyso5jYIJRhlVdQtSqZrbtnWKdVa02HKpdSdqZ6XjFmldd52rLG_QuoqJ6qx4f9Q9zO2AzubRAXpzCH6AcGsm8ObvyuivzH66MUIqml8WeHMvEKbvc77ODD5a7HsYcZqjYZo2Ou-mFvT1P-j1NIcxn2d4wxpRM850ptiRsmGKMWD3sAyjZjHXHM012dgltOG559WfVzx0_HIzA_wIxFwa9xh-j_6_6h2oKLDm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2919481217</pqid></control><display><type>article</type><title>Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes After Cardiac Arrest and Targeted Temperature Management</title><source>MEDLINE</source><source>ProQuest Central (Alumni)</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Deng, Ruoxian ; Koenig, Matthew A. ; Young, Leanne Moon ; Jia, Xiaofeng</creator><creatorcontrib>Deng, Ruoxian ; Koenig, Matthew A. ; Young, Leanne Moon ; Jia, Xiaofeng</creatorcontrib><description>Background
Brain recovery after cardiac arrest (CA) is sensitive to temperature. Yet the effect of temperature management on different EEG frequency bands has not been elucidated. A novel quantitative EEG algorithm, sub-band information quantity (SIQ), was applied to evaluate EEG recovery and outcomes after CA.
Methods
Twenty-four Wistar rats undergoing 7-min CA were randomly assigned to immediate hypothermia (32–34 °C), normothermia (36.5–37.5 °C), or hyperthermia (38.5–39.5 °C) (
n
= 8). EEG was recorded continuously for the first 8 h and then for serial 30-min epochs daily. The neurologic deficit score (NDS) at 72-h was the primary functional outcome. Another four rats without brain injury were added as a control.
Results
Better recovery of gamma-band SIQ was found in the hypothermia group (0.60 ± 0.03) compared with the normothermia group (0.40 ± 0.03) (
p
< 0.01) and in the normothermia group compared with the hyperthermia group (0.34 ± 0.03) (
p
< 0.05). The NDS was also improved in the lower temperature groups: hypothermia [median (25th, 75th), 74 (61, 74)] versus normothermia [49 (47, 61)] versus hyperthermia [43 (0, 50)] (
p
< 0.01). Throughout the 72-h experiment, the gamma-band SIQ showed the strongest correlation at every time point (ranging 0.520–0.788 from 30-min to 72-h post-resuscitation, all
p
< 0.05) whereas the delta-band SIQ had poor correlation with the 72-h NDS. No significant difference of sub-band EEG was found with temperature manipulation alone.
Conclusions
Recovery of gamma-band SIQ-qEEG was strongly associated with functional outcomes after CA. Induced hypothermia was associated with faster recovery of gamma-band SIQ and improved functional outcomes. Targeted temperature management primarily affected gamma frequency oscillations but not delta rhythm.</description><identifier>ISSN: 1541-6933</identifier><identifier>EISSN: 1556-0961</identifier><identifier>DOI: 10.1007/s12028-015-0157-2</identifier><identifier>PMID: 26130405</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Algorithms ; Animals ; Behavior, Animal - physiology ; Biomarkers ; Blood pressure ; Body Temperature - physiology ; Cardiac arrest ; Critical Care Medicine ; Electroencephalography ; Electroencephalography - methods ; Fever ; Gamma Rhythm - physiology ; Heart Arrest - physiopathology ; Heart Arrest - therapy ; Hyperthermia ; Hyperthermia, Induced ; Hypothermia ; Hypothermia, Induced ; Intensive ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Neurology ; Rats ; Rats, Wistar ; Recovery of Function - physiology ; Translational Research ; Traumatic brain injury ; Ventilators ; Wavelet transforms</subject><ispartof>Neurocritical care, 2015-10, Vol.23 (2), p.262-273</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>Springer Science+Business Media New York 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-53dd7e414101068ba56682cbbd61fc4beb2577f48dc5d2ce088ffd3c29ecd3143</citedby><cites>FETCH-LOGICAL-c540t-53dd7e414101068ba56682cbbd61fc4beb2577f48dc5d2ce088ffd3c29ecd3143</cites><orcidid>0000-0003-1445-8525</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12028-015-0157-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919481217?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,777,781,882,21369,21370,27905,27906,33511,33512,33725,33726,41469,42538,43640,43786,51300,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26130405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Ruoxian</creatorcontrib><creatorcontrib>Koenig, Matthew A.</creatorcontrib><creatorcontrib>Young, Leanne Moon</creatorcontrib><creatorcontrib>Jia, Xiaofeng</creatorcontrib><title>Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes After Cardiac Arrest and Targeted Temperature Management</title><title>Neurocritical care</title><addtitle>Neurocrit Care</addtitle><addtitle>Neurocrit Care</addtitle><description>Background
Brain recovery after cardiac arrest (CA) is sensitive to temperature. Yet the effect of temperature management on different EEG frequency bands has not been elucidated. A novel quantitative EEG algorithm, sub-band information quantity (SIQ), was applied to evaluate EEG recovery and outcomes after CA.
Methods
Twenty-four Wistar rats undergoing 7-min CA were randomly assigned to immediate hypothermia (32–34 °C), normothermia (36.5–37.5 °C), or hyperthermia (38.5–39.5 °C) (
n
= 8). EEG was recorded continuously for the first 8 h and then for serial 30-min epochs daily. The neurologic deficit score (NDS) at 72-h was the primary functional outcome. Another four rats without brain injury were added as a control.
Results
Better recovery of gamma-band SIQ was found in the hypothermia group (0.60 ± 0.03) compared with the normothermia group (0.40 ± 0.03) (
p
< 0.01) and in the normothermia group compared with the hyperthermia group (0.34 ± 0.03) (
p
< 0.05). The NDS was also improved in the lower temperature groups: hypothermia [median (25th, 75th), 74 (61, 74)] versus normothermia [49 (47, 61)] versus hyperthermia [43 (0, 50)] (
p
< 0.01). Throughout the 72-h experiment, the gamma-band SIQ showed the strongest correlation at every time point (ranging 0.520–0.788 from 30-min to 72-h post-resuscitation, all
p
< 0.05) whereas the delta-band SIQ had poor correlation with the 72-h NDS. No significant difference of sub-band EEG was found with temperature manipulation alone.
Conclusions
Recovery of gamma-band SIQ-qEEG was strongly associated with functional outcomes after CA. Induced hypothermia was associated with faster recovery of gamma-band SIQ and improved functional outcomes. Targeted temperature management primarily affected gamma frequency oscillations but not delta rhythm.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>Body Temperature - physiology</subject><subject>Cardiac arrest</subject><subject>Critical Care Medicine</subject><subject>Electroencephalography</subject><subject>Electroencephalography - methods</subject><subject>Fever</subject><subject>Gamma Rhythm - physiology</subject><subject>Heart Arrest - physiopathology</subject><subject>Heart Arrest - therapy</subject><subject>Hyperthermia</subject><subject>Hyperthermia, Induced</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recovery of Function - physiology</subject><subject>Translational Research</subject><subject>Traumatic brain injury</subject><subject>Ventilators</subject><subject>Wavelet transforms</subject><issn>1541-6933</issn><issn>1556-0961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU2LFDEQhhtR3HX1B3iRgBcvrUk6H90XYRxmR2FlEcZzqE6qZ7P2x5ikV_bgf980s64fIKFIQT31VhVvUbxk9C2jVL-LjFNel5TJJXTJHxWnTEpV0kaxx0suWKmaqjopnsV4TSnXjZZPixOuWEUFlafFzw2E_pZ8mWFMPkHyN0i2MAxQfoDRkc1mSz5D-IaB-EhWMU7WQ0JHfvh0RS7nZKcBc6FLmVhDcB4sWYWAMZGlfwdhjwu_w-GAAdIcMAuOsMcBx_S8eNJBH_HF_X9WfD3f7NYfy4vL7af16qK0UtBUyso5jYIJRhlVdQtSqZrbtnWKdVa02HKpdSdqZ6XjFmldd52rLG_QuoqJ6qx4f9Q9zO2AzubRAXpzCH6AcGsm8ObvyuivzH66MUIqml8WeHMvEKbvc77ODD5a7HsYcZqjYZo2Ou-mFvT1P-j1NIcxn2d4wxpRM850ptiRsmGKMWD3sAyjZjHXHM012dgltOG559WfVzx0_HIzA_wIxFwa9xh-j_6_6h2oKLDm</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Deng, Ruoxian</creator><creator>Koenig, Matthew A.</creator><creator>Young, Leanne Moon</creator><creator>Jia, Xiaofeng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1445-8525</orcidid></search><sort><creationdate>20151001</creationdate><title>Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes After Cardiac Arrest and Targeted Temperature Management</title><author>Deng, Ruoxian ; Koenig, Matthew A. ; Young, Leanne Moon ; Jia, Xiaofeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-53dd7e414101068ba56682cbbd61fc4beb2577f48dc5d2ce088ffd3c29ecd3143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Biomarkers</topic><topic>Blood pressure</topic><topic>Body Temperature - physiology</topic><topic>Cardiac arrest</topic><topic>Critical Care Medicine</topic><topic>Electroencephalography</topic><topic>Electroencephalography - methods</topic><topic>Fever</topic><topic>Gamma Rhythm - physiology</topic><topic>Heart Arrest - physiopathology</topic><topic>Heart Arrest - therapy</topic><topic>Hyperthermia</topic><topic>Hyperthermia, Induced</topic><topic>Hypothermia</topic><topic>Hypothermia, Induced</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recovery of Function - physiology</topic><topic>Translational Research</topic><topic>Traumatic brain injury</topic><topic>Ventilators</topic><topic>Wavelet transforms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Ruoxian</creatorcontrib><creatorcontrib>Koenig, Matthew A.</creatorcontrib><creatorcontrib>Young, Leanne Moon</creatorcontrib><creatorcontrib>Jia, Xiaofeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurocritical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Ruoxian</au><au>Koenig, Matthew A.</au><au>Young, Leanne Moon</au><au>Jia, Xiaofeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes After Cardiac Arrest and Targeted Temperature Management</atitle><jtitle>Neurocritical care</jtitle><stitle>Neurocrit Care</stitle><addtitle>Neurocrit Care</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>23</volume><issue>2</issue><spage>262</spage><epage>273</epage><pages>262-273</pages><issn>1541-6933</issn><eissn>1556-0961</eissn><abstract>Background
Brain recovery after cardiac arrest (CA) is sensitive to temperature. Yet the effect of temperature management on different EEG frequency bands has not been elucidated. A novel quantitative EEG algorithm, sub-band information quantity (SIQ), was applied to evaluate EEG recovery and outcomes after CA.
Methods
Twenty-four Wistar rats undergoing 7-min CA were randomly assigned to immediate hypothermia (32–34 °C), normothermia (36.5–37.5 °C), or hyperthermia (38.5–39.5 °C) (
n
= 8). EEG was recorded continuously for the first 8 h and then for serial 30-min epochs daily. The neurologic deficit score (NDS) at 72-h was the primary functional outcome. Another four rats without brain injury were added as a control.
Results
Better recovery of gamma-band SIQ was found in the hypothermia group (0.60 ± 0.03) compared with the normothermia group (0.40 ± 0.03) (
p
< 0.01) and in the normothermia group compared with the hyperthermia group (0.34 ± 0.03) (
p
< 0.05). The NDS was also improved in the lower temperature groups: hypothermia [median (25th, 75th), 74 (61, 74)] versus normothermia [49 (47, 61)] versus hyperthermia [43 (0, 50)] (
p
< 0.01). Throughout the 72-h experiment, the gamma-band SIQ showed the strongest correlation at every time point (ranging 0.520–0.788 from 30-min to 72-h post-resuscitation, all
p
< 0.05) whereas the delta-band SIQ had poor correlation with the 72-h NDS. No significant difference of sub-band EEG was found with temperature manipulation alone.
Conclusions
Recovery of gamma-band SIQ-qEEG was strongly associated with functional outcomes after CA. Induced hypothermia was associated with faster recovery of gamma-band SIQ and improved functional outcomes. Targeted temperature management primarily affected gamma frequency oscillations but not delta rhythm.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26130405</pmid><doi>10.1007/s12028-015-0157-2</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1445-8525</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1541-6933 |
| ispartof | Neurocritical care, 2015-10, Vol.23 (2), p.262-273 |
| issn | 1541-6933 1556-0961 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4560606 |
| source | MEDLINE; ProQuest Central (Alumni); SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Algorithms Animals Behavior, Animal - physiology Biomarkers Blood pressure Body Temperature - physiology Cardiac arrest Critical Care Medicine Electroencephalography Electroencephalography - methods Fever Gamma Rhythm - physiology Heart Arrest - physiopathology Heart Arrest - therapy Hyperthermia Hyperthermia, Induced Hypothermia Hypothermia, Induced Intensive Internal Medicine Male Medicine Medicine & Public Health Neurology Rats Rats, Wistar Recovery of Function - physiology Translational Research Traumatic brain injury Ventilators Wavelet transforms |
| title | Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes After Cardiac Arrest and Targeted Temperature Management |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T17%3A36%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20Quantitative%20Gamma-Band%20EEG%20Marker%20is%20Associated%20with%20Outcomes%20After%20Cardiac%20Arrest%20and%20Targeted%20Temperature%20Management&rft.jtitle=Neurocritical%20care&rft.au=Deng,%20Ruoxian&rft.date=2015-10-01&rft.volume=23&rft.issue=2&rft.spage=262&rft.epage=273&rft.pages=262-273&rft.issn=1541-6933&rft.eissn=1556-0961&rft_id=info:doi/10.1007/s12028-015-0157-2&rft_dat=%3Cproquest_pubme%3E1709710666%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2919481217&rft_id=info:pmid/26130405&rfr_iscdi=true |