Red blood cell transfusion-induced inflammation: myth or reality

Red blood cells (RBCs) destined for transfusion can be refrigerator‐stored for up to 42 days prior to transfusion. Our studies in mice and dogs suggest that transfusion of older, stored RBCs, but not fresh RBCs, produce acute elevations in circulating pro‐inflammatory cytokine levels. Although our s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ISBT science series 2015-04, Vol.10 (S1), p.188-191
1. Verfasser: Hod, E. A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 191
container_issue S1
container_start_page 188
container_title ISBT science series
container_volume 10
creator Hod, E. A.
description Red blood cells (RBCs) destined for transfusion can be refrigerator‐stored for up to 42 days prior to transfusion. Our studies in mice and dogs suggest that transfusion of older, stored RBCs, but not fresh RBCs, produce acute elevations in circulating pro‐inflammatory cytokine levels. Although our study in healthy adult human volunteers failed to demonstrate a pro‐inflammatory cytokine response following transfusion of RBCs stored for 40–42 days, a recent study in preterm infants suggests that RBC transfusions are associated with a pro‐inflammatory response. Thus, whether RBC transfusions, particularly of older, stored RBCs, result in a pro‐inflammatory cytokine response, is still an unresolved issue. Animal studies suggest this to be true, yet human studies have yet to demonstrate definitively that such an inflammatory response occurs. Potential explanations for this include differences between human and animal biology, the dose of RBCs transfused and baseline differences in levels of inflammation. This review will summarize the currently available evidence and approaches to resolving whether transfusions of older, stored RBCs are associated with inflammation in recipients.
doi_str_mv 10.1111/voxs.12108
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4560364</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3652854781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4168-84e332eb4856d8d636e8acfb69e47efbe3279c9d43e70a21bb59ed4ff5cf4b643</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi1UxJaFCz8AReqlQkrrr9gOB1S0gqXSiqLysYiL5SRj6pLEi52U3X-Pt9uugANz8cjzzKt39CL0jOATkur0xq_jCaEEqwfokMiC5FRRfrDviZigxzFeY1xwJfkjNKGCcakwPkRnl9BkVet9k9XQttkQTB_tGJ3vc9c3Y53Grret6TozpM-XWbcZrjIfsgCmdcPmCXpoTRvh6d07RZ_fvvk0e5cvLubns9eLvOZEqFxxYIxCxVUhGtUIJkCZ2laiBC7BVsCoLOuy4QwkNpRUVVFCw60tassrwdkUvdrprsaqg6aGPllt9Sq4zoSN9sbpvye9u9Lf_Y3mhcDsVuD4TiD4nyPEQXcubm82PfgxaqKoEIzSEif06B_02o-hT-dpIiQVVGLBEvViR9XBxxjA7s0QrLfB6G0w-jaYBD__0_4evU8iAWQH_HItbP4jpb9cfP14L5rvdlwcYL3fMeGHFpLJQi_fz_XiEvNvdPFBL9lvicCpJQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1672627063</pqid></control><display><type>article</type><title>Red blood cell transfusion-induced inflammation: myth or reality</title><source>Access via Wiley Online Library</source><creator>Hod, E. A.</creator><creatorcontrib>Hod, E. A.</creatorcontrib><description>Red blood cells (RBCs) destined for transfusion can be refrigerator‐stored for up to 42 days prior to transfusion. Our studies in mice and dogs suggest that transfusion of older, stored RBCs, but not fresh RBCs, produce acute elevations in circulating pro‐inflammatory cytokine levels. Although our study in healthy adult human volunteers failed to demonstrate a pro‐inflammatory cytokine response following transfusion of RBCs stored for 40–42 days, a recent study in preterm infants suggests that RBC transfusions are associated with a pro‐inflammatory response. Thus, whether RBC transfusions, particularly of older, stored RBCs, result in a pro‐inflammatory cytokine response, is still an unresolved issue. Animal studies suggest this to be true, yet human studies have yet to demonstrate definitively that such an inflammatory response occurs. Potential explanations for this include differences between human and animal biology, the dose of RBCs transfused and baseline differences in levels of inflammation. This review will summarize the currently available evidence and approaches to resolving whether transfusions of older, stored RBCs are associated with inflammation in recipients.</description><identifier>ISSN: 1751-2816</identifier><identifier>EISSN: 1751-2824</identifier><identifier>DOI: 10.1111/voxs.12108</identifier><identifier>PMID: 26347800</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>monocyte chemoattractant protein-1 ; non-transferrin-bound iron ; RBC transfusion</subject><ispartof>ISBT science series, 2015-04, Vol.10 (S1), p.188-191</ispartof><rights>2015 International Society of Blood Transfusion</rights><rights>Copyright ISBT Science Series © 2015 International Society of Blood Transfusion</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4168-84e332eb4856d8d636e8acfb69e47efbe3279c9d43e70a21bb59ed4ff5cf4b643</citedby><cites>FETCH-LOGICAL-c4168-84e332eb4856d8d636e8acfb69e47efbe3279c9d43e70a21bb59ed4ff5cf4b643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvoxs.12108$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvoxs.12108$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26347800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hod, E. A.</creatorcontrib><title>Red blood cell transfusion-induced inflammation: myth or reality</title><title>ISBT science series</title><addtitle>VOXS</addtitle><description>Red blood cells (RBCs) destined for transfusion can be refrigerator‐stored for up to 42 days prior to transfusion. Our studies in mice and dogs suggest that transfusion of older, stored RBCs, but not fresh RBCs, produce acute elevations in circulating pro‐inflammatory cytokine levels. Although our study in healthy adult human volunteers failed to demonstrate a pro‐inflammatory cytokine response following transfusion of RBCs stored for 40–42 days, a recent study in preterm infants suggests that RBC transfusions are associated with a pro‐inflammatory response. Thus, whether RBC transfusions, particularly of older, stored RBCs, result in a pro‐inflammatory cytokine response, is still an unresolved issue. Animal studies suggest this to be true, yet human studies have yet to demonstrate definitively that such an inflammatory response occurs. Potential explanations for this include differences between human and animal biology, the dose of RBCs transfused and baseline differences in levels of inflammation. This review will summarize the currently available evidence and approaches to resolving whether transfusions of older, stored RBCs are associated with inflammation in recipients.</description><subject>monocyte chemoattractant protein-1</subject><subject>non-transferrin-bound iron</subject><subject>RBC transfusion</subject><issn>1751-2816</issn><issn>1751-2824</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi1UxJaFCz8AReqlQkrrr9gOB1S0gqXSiqLysYiL5SRj6pLEi52U3X-Pt9uugANz8cjzzKt39CL0jOATkur0xq_jCaEEqwfokMiC5FRRfrDviZigxzFeY1xwJfkjNKGCcakwPkRnl9BkVet9k9XQttkQTB_tGJ3vc9c3Y53Grret6TozpM-XWbcZrjIfsgCmdcPmCXpoTRvh6d07RZ_fvvk0e5cvLubns9eLvOZEqFxxYIxCxVUhGtUIJkCZ2laiBC7BVsCoLOuy4QwkNpRUVVFCw60tassrwdkUvdrprsaqg6aGPllt9Sq4zoSN9sbpvye9u9Lf_Y3mhcDsVuD4TiD4nyPEQXcubm82PfgxaqKoEIzSEif06B_02o-hT-dpIiQVVGLBEvViR9XBxxjA7s0QrLfB6G0w-jaYBD__0_4evU8iAWQH_HItbP4jpb9cfP14L5rvdlwcYL3fMeGHFpLJQi_fz_XiEvNvdPFBL9lvicCpJQ</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Hod, E. A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201504</creationdate><title>Red blood cell transfusion-induced inflammation: myth or reality</title><author>Hod, E. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4168-84e332eb4856d8d636e8acfb69e47efbe3279c9d43e70a21bb59ed4ff5cf4b643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>monocyte chemoattractant protein-1</topic><topic>non-transferrin-bound iron</topic><topic>RBC transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hod, E. A.</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ISBT science series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hod, E. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red blood cell transfusion-induced inflammation: myth or reality</atitle><jtitle>ISBT science series</jtitle><addtitle>VOXS</addtitle><date>2015-04</date><risdate>2015</risdate><volume>10</volume><issue>S1</issue><spage>188</spage><epage>191</epage><pages>188-191</pages><issn>1751-2816</issn><eissn>1751-2824</eissn><abstract>Red blood cells (RBCs) destined for transfusion can be refrigerator‐stored for up to 42 days prior to transfusion. Our studies in mice and dogs suggest that transfusion of older, stored RBCs, but not fresh RBCs, produce acute elevations in circulating pro‐inflammatory cytokine levels. Although our study in healthy adult human volunteers failed to demonstrate a pro‐inflammatory cytokine response following transfusion of RBCs stored for 40–42 days, a recent study in preterm infants suggests that RBC transfusions are associated with a pro‐inflammatory response. Thus, whether RBC transfusions, particularly of older, stored RBCs, result in a pro‐inflammatory cytokine response, is still an unresolved issue. Animal studies suggest this to be true, yet human studies have yet to demonstrate definitively that such an inflammatory response occurs. Potential explanations for this include differences between human and animal biology, the dose of RBCs transfused and baseline differences in levels of inflammation. This review will summarize the currently available evidence and approaches to resolving whether transfusions of older, stored RBCs are associated with inflammation in recipients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26347800</pmid><doi>10.1111/voxs.12108</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1751-2816
ispartof ISBT science series, 2015-04, Vol.10 (S1), p.188-191
issn 1751-2816
1751-2824
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4560364
source Access via Wiley Online Library
subjects monocyte chemoattractant protein-1
non-transferrin-bound iron
RBC transfusion
title Red blood cell transfusion-induced inflammation: myth or reality
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T22%3A24%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Red%20blood%20cell%20transfusion-induced%20inflammation:%20myth%20or%20reality&rft.jtitle=ISBT%20science%20series&rft.au=Hod,%20E.%20A.&rft.date=2015-04&rft.volume=10&rft.issue=S1&rft.spage=188&rft.epage=191&rft.pages=188-191&rft.issn=1751-2816&rft.eissn=1751-2824&rft_id=info:doi/10.1111/voxs.12108&rft_dat=%3Cproquest_pubme%3E3652854781%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1672627063&rft_id=info:pmid/26347800&rfr_iscdi=true