Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study
It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic function through the dorsomedial hypothalamus in relation to obesity. Here, we investigated...
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| Veröffentlicht in: | Cardiovascular Diabetology 2015-09, Vol.14 (1), p.117-117, Article 117 |
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| creator | Kurajoh, Masafumi Koyama, Hidenori Kadoya, Manabu Naka, Mariko Miyoshi, Akio Kanzaki, Akinori Kakutani-Hatayama, Miki Okazaki, Hirokazu Shoji, Takuhito Moriwaki, Yuji Yamamoto, Tetsuya Emoto, Masanori Inaba, Masaaki Namba, Mitsuyoshi |
| description | It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic function through the dorsomedial hypothalamus in relation to obesity. Here, we investigated the mutual relationships among plasma leptin, visceral fat accumulation, and cardiac autonomic dysfunction in patients with type 2 diabetes.
This cross-sectional study included 100 diabetic patients, and 100 age- and gender-matched non-diabetic patients with cardiovascular risk factors. Plasma leptin and soluble leptin receptor levels, visceral fat area (VFA), and heart rate variability (HRV) were determined in addition to classical cardiovascular risk factors.
In the type 2 diabetic patients, VFA was significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.238), while the plasma level of leptin, but not soluble leptin receptor, was also significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.231). Multiple regression analysis showed that plasma leptin was significantly associated with SDNN and SDANN5 independent of other factors, including age, gender, presence of hypertension and dyslipidemia, duration of diabetes, HbA1c, and eGFR. Furthermore, the relationship of leptin with SDNN and SDANN5 (β = -0.279 and -0.254, respectively) remained significant (p < 0.05) after adjustment for VFA. In patients without diabetes, no significant associations were observed between leptin and any of the HRV parameters.
Hyperleptinemia may be involved in cardiac autonomic dysfunction in patients with type 2 diabetes and visceral obesity. |
| doi_str_mv | 10.1186/s12933-015-0280-6 |
| format | Article |
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This cross-sectional study included 100 diabetic patients, and 100 age- and gender-matched non-diabetic patients with cardiovascular risk factors. Plasma leptin and soluble leptin receptor levels, visceral fat area (VFA), and heart rate variability (HRV) were determined in addition to classical cardiovascular risk factors.
In the type 2 diabetic patients, VFA was significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.238), while the plasma level of leptin, but not soluble leptin receptor, was also significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.231). Multiple regression analysis showed that plasma leptin was significantly associated with SDNN and SDANN5 independent of other factors, including age, gender, presence of hypertension and dyslipidemia, duration of diabetes, HbA1c, and eGFR. Furthermore, the relationship of leptin with SDNN and SDANN5 (β = -0.279 and -0.254, respectively) remained significant (p < 0.05) after adjustment for VFA. In patients without diabetes, no significant associations were observed between leptin and any of the HRV parameters.
Hyperleptinemia may be involved in cardiac autonomic dysfunction in patients with type 2 diabetes and visceral obesity.</description><identifier>ISSN: 1475-2840</identifier><identifier>EISSN: 1475-2840</identifier><identifier>DOI: 10.1186/s12933-015-0280-6</identifier><identifier>PMID: 26338087</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adiposity ; Aged ; Analysis ; Autonomic Nervous System - physiopathology ; Biomarkers - blood ; Care and treatment ; Case-Control Studies ; Chi-Square Distribution ; Complications and side effects ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - physiopathology ; Female ; Glycosylated hemoglobin ; Health aspects ; Heart - innervation ; Heart Diseases - blood ; Heart Diseases - diagnosis ; Heart Diseases - etiology ; Heart Diseases - physiopathology ; Heart Rate ; Humans ; Hypertension ; Intra-Abdominal Fat - metabolism ; Intra-Abdominal Fat - physiopathology ; Leptin ; Leptin - blood ; Male ; Middle Aged ; Multivariate Analysis ; Obesity - blood ; Obesity - complications ; Obesity - diagnosis ; Obesity - physiopathology ; Original Investigation ; Receptors, Leptin - blood ; Risk Factors ; Up-Regulation</subject><ispartof>Cardiovascular Diabetology, 2015-09, Vol.14 (1), p.117-117, Article 117</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Kurajoh et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-638cd29a0b852f8e72f846944bd58410da8ff1efd363d1eb4e1ed812beaca4d23</citedby><cites>FETCH-LOGICAL-c494t-638cd29a0b852f8e72f846944bd58410da8ff1efd363d1eb4e1ed812beaca4d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560071/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560071/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26338087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurajoh, Masafumi</creatorcontrib><creatorcontrib>Koyama, Hidenori</creatorcontrib><creatorcontrib>Kadoya, Manabu</creatorcontrib><creatorcontrib>Naka, Mariko</creatorcontrib><creatorcontrib>Miyoshi, Akio</creatorcontrib><creatorcontrib>Kanzaki, Akinori</creatorcontrib><creatorcontrib>Kakutani-Hatayama, Miki</creatorcontrib><creatorcontrib>Okazaki, Hirokazu</creatorcontrib><creatorcontrib>Shoji, Takuhito</creatorcontrib><creatorcontrib>Moriwaki, Yuji</creatorcontrib><creatorcontrib>Yamamoto, Tetsuya</creatorcontrib><creatorcontrib>Emoto, Masanori</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><creatorcontrib>Namba, Mitsuyoshi</creatorcontrib><title>Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study</title><title>Cardiovascular Diabetology</title><addtitle>Cardiovasc Diabetol</addtitle><description>It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic function through the dorsomedial hypothalamus in relation to obesity. Here, we investigated the mutual relationships among plasma leptin, visceral fat accumulation, and cardiac autonomic dysfunction in patients with type 2 diabetes.
This cross-sectional study included 100 diabetic patients, and 100 age- and gender-matched non-diabetic patients with cardiovascular risk factors. Plasma leptin and soluble leptin receptor levels, visceral fat area (VFA), and heart rate variability (HRV) were determined in addition to classical cardiovascular risk factors.
In the type 2 diabetic patients, VFA was significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.238), while the plasma level of leptin, but not soluble leptin receptor, was also significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.231). Multiple regression analysis showed that plasma leptin was significantly associated with SDNN and SDANN5 independent of other factors, including age, gender, presence of hypertension and dyslipidemia, duration of diabetes, HbA1c, and eGFR. Furthermore, the relationship of leptin with SDNN and SDANN5 (β = -0.279 and -0.254, respectively) remained significant (p < 0.05) after adjustment for VFA. In patients without diabetes, no significant associations were observed between leptin and any of the HRV parameters.
Hyperleptinemia may be involved in cardiac autonomic dysfunction in patients with type 2 diabetes and visceral obesity.</description><subject>Adiposity</subject><subject>Aged</subject><subject>Analysis</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Biomarkers - blood</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Complications and side effects</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Female</subject><subject>Glycosylated hemoglobin</subject><subject>Health aspects</subject><subject>Heart - innervation</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - diagnosis</subject><subject>Heart Diseases - etiology</subject><subject>Heart Diseases - physiopathology</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Intra-Abdominal Fat - physiopathology</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - diagnosis</subject><subject>Obesity - physiopathology</subject><subject>Original Investigation</subject><subject>Receptors, Leptin - blood</subject><subject>Risk Factors</subject><subject>Up-Regulation</subject><issn>1475-2840</issn><issn>1475-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdUk1rFTEUHUSxtfoD3EjAjZup-Zok40J4PNQKBQV1HTLJnTZlJhmTTMv79-YxtVQJ5IbknHM_cprmNcHnhCjxPhPaM9Zi0rWYKtyKJ80p4bJrqeL46aPzSfMi5xuMiVSCPG9OqGBMYSVPm_R9Mnk2aIKl-FDDLUzIZ2RyjtabAg7d-XKNrEnOG4vMWmKIs7fIHfK4Blt8DKgyF1M8hJI3eDksgCiqlAEK5A_o4sd-t0O5rO7wsnk2minDq_t41vz6_Onn_qK9_Pbl63532Vre89IKpqyjvcGD6uioQNaNi57zwXWKE-yMGkcCo2OCOQIDBwJOETqAsYY7ys6aj5vusg4zOFurS2bSS_KzSQcdjdf_vgR_ra_ireadwFiSKvDuXiDF3yvkomefLUyTCRDXrInEvawzlrJC3_4HvYlrCrW9ilIY95x1oqLON9SVmUD7MMaa19bloE40Bhh9vd91vIpiyo8tkI1gU8w5wfhQPcH6aAG9WUBXC-ijBfQxyZvHbT8w_v45-wOjyK4E</recordid><startdate>20150904</startdate><enddate>20150904</enddate><creator>Kurajoh, Masafumi</creator><creator>Koyama, Hidenori</creator><creator>Kadoya, Manabu</creator><creator>Naka, Mariko</creator><creator>Miyoshi, Akio</creator><creator>Kanzaki, Akinori</creator><creator>Kakutani-Hatayama, Miki</creator><creator>Okazaki, Hirokazu</creator><creator>Shoji, Takuhito</creator><creator>Moriwaki, Yuji</creator><creator>Yamamoto, Tetsuya</creator><creator>Emoto, Masanori</creator><creator>Inaba, Masaaki</creator><creator>Namba, Mitsuyoshi</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150904</creationdate><title>Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study</title><author>Kurajoh, Masafumi ; Koyama, Hidenori ; Kadoya, Manabu ; Naka, Mariko ; Miyoshi, Akio ; Kanzaki, Akinori ; Kakutani-Hatayama, Miki ; Okazaki, Hirokazu ; Shoji, Takuhito ; Moriwaki, Yuji ; Yamamoto, Tetsuya ; Emoto, Masanori ; Inaba, Masaaki ; Namba, Mitsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-638cd29a0b852f8e72f846944bd58410da8ff1efd363d1eb4e1ed812beaca4d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adiposity</topic><topic>Aged</topic><topic>Analysis</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Biomarkers - blood</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Complications and side effects</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Female</topic><topic>Glycosylated hemoglobin</topic><topic>Health aspects</topic><topic>Heart - innervation</topic><topic>Heart Diseases - blood</topic><topic>Heart Diseases - diagnosis</topic><topic>Heart Diseases - etiology</topic><topic>Heart Diseases - physiopathology</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Intra-Abdominal Fat - metabolism</topic><topic>Intra-Abdominal Fat - physiopathology</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obesity - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiovascular Diabetology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurajoh, Masafumi</au><au>Koyama, Hidenori</au><au>Kadoya, Manabu</au><au>Naka, Mariko</au><au>Miyoshi, Akio</au><au>Kanzaki, Akinori</au><au>Kakutani-Hatayama, Miki</au><au>Okazaki, Hirokazu</au><au>Shoji, Takuhito</au><au>Moriwaki, Yuji</au><au>Yamamoto, Tetsuya</au><au>Emoto, Masanori</au><au>Inaba, Masaaki</au><au>Namba, Mitsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study</atitle><jtitle>Cardiovascular Diabetology</jtitle><addtitle>Cardiovasc Diabetol</addtitle><date>2015-09-04</date><risdate>2015</risdate><volume>14</volume><issue>1</issue><spage>117</spage><epage>117</epage><pages>117-117</pages><artnum>117</artnum><issn>1475-2840</issn><eissn>1475-2840</eissn><abstract>It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic function through the dorsomedial hypothalamus in relation to obesity. Here, we investigated the mutual relationships among plasma leptin, visceral fat accumulation, and cardiac autonomic dysfunction in patients with type 2 diabetes.
This cross-sectional study included 100 diabetic patients, and 100 age- and gender-matched non-diabetic patients with cardiovascular risk factors. Plasma leptin and soluble leptin receptor levels, visceral fat area (VFA), and heart rate variability (HRV) were determined in addition to classical cardiovascular risk factors.
In the type 2 diabetic patients, VFA was significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.238), while the plasma level of leptin, but not soluble leptin receptor, was also significantly (p < 0.05) and inversely associated with HRV parameters (SDNN: r = -0.243; SDANN5: r = -0.231). Multiple regression analysis showed that plasma leptin was significantly associated with SDNN and SDANN5 independent of other factors, including age, gender, presence of hypertension and dyslipidemia, duration of diabetes, HbA1c, and eGFR. Furthermore, the relationship of leptin with SDNN and SDANN5 (β = -0.279 and -0.254, respectively) remained significant (p < 0.05) after adjustment for VFA. In patients without diabetes, no significant associations were observed between leptin and any of the HRV parameters.
Hyperleptinemia may be involved in cardiac autonomic dysfunction in patients with type 2 diabetes and visceral obesity.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26338087</pmid><doi>10.1186/s12933-015-0280-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Adiposity Aged Analysis Autonomic Nervous System - physiopathology Biomarkers - blood Care and treatment Case-Control Studies Chi-Square Distribution Complications and side effects Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - physiopathology Female Glycosylated hemoglobin Health aspects Heart - innervation Heart Diseases - blood Heart Diseases - diagnosis Heart Diseases - etiology Heart Diseases - physiopathology Heart Rate Humans Hypertension Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - physiopathology Leptin Leptin - blood Male Middle Aged Multivariate Analysis Obesity - blood Obesity - complications Obesity - diagnosis Obesity - physiopathology Original Investigation Receptors, Leptin - blood Risk Factors Up-Regulation |
| title | Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study |
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