Blunted responses to reward in remitted post‐traumatic stress disorder
Background Recent evidence suggests blunted responses to rewarding stimuli in patients with post‐traumatic stress disorder (PTSD). However, it is not clear whether these alterations in reward processing normalize in remitted PTSD patients. Methods We tested behavioral and physiological responses to...
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| Veröffentlicht in: | Brain and behavior 2015-08, Vol.5 (8), p.e00357-n/a |
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| creator | Kalebasi, Nilufer Kuelen, Eveline Schnyder, Ulrich Schumacher, Sonja Mueller‐Pfeiffer, Christoph Wilhelm, Frank H. Athilingam, Jegath Moergeli, Hanspeter Martin‐Soelch, Chantal |
| description | Background
Recent evidence suggests blunted responses to rewarding stimuli in patients with post‐traumatic stress disorder (PTSD). However, it is not clear whether these alterations in reward processing normalize in remitted PTSD patients.
Methods
We tested behavioral and physiological responses to monetary reward in a spatial memory task in 13 accident survivors with remitted PTSD, 14 accident survivors who never had PTSD, and 16 nontrauma‐exposed subjects. All accident survivors were recruited from two samples of severely physically injured patients, who had participated in previous prospective studies on the incidence of PTSD after accidental injury approximately 10 years ago. Reaction time, accuracy, skin conductance responses, and self‐reported mood were assessed during the task.
Results
Accident survivors who never had PTSD and nontrauma exposed controls reported significantly higher positive mood in the reinforced versus nonreinforced condition (P |
| doi_str_mv | 10.1002/brb3.357 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4559020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1711545465</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5417-c347f2b1ade0e01971b56e563a45907e0303505299cf477320f2ece659d9c7483</originalsourceid><addsrcrecordid>eNp1kc1KxDAUhYMoKjrgE0jBjZuO-W2mG8ER_2BAEF2HNL3VDG0zJq3izkfwGX0SUxyHUTCb3HC_nHuSg9ABwWOCMT0pfMHGTMgNtEtJRlNGZb65Vu-gUQhzHJcgnHK8jXZoFnmR4110Pa37toMy8RAWrg0Qks7Fw6v2ZWLbWDW2G_oLF7rP94_O677RnTVJ6OKVkJQ2OF-C30dbla4DjJb7Hnq4vLg_v05nt1c352ez1AhOZGoYlxUtiC4BAya5JIXIQGRM8-hHAmaYCSxonpuKS8korigYyERe5kbyCdtDp9-6i75ooDTQRku1WnjbaP-mnLbqd6e1T-rRvSgu4gCKo8DxUsC75x5CpxobDNS1bsH1QRFJiOCCZyKiR3_Quet9G5-nKJ1MGKUsWlwJGu9C8FCtzBCshoTUkJCKPx7Rw3XzK_Anjwik38CrreHtXyE1vZuyQfALH2eaZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2288322377</pqid></control><display><type>article</type><title>Blunted responses to reward in remitted post‐traumatic stress disorder</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Kalebasi, Nilufer ; Kuelen, Eveline ; Schnyder, Ulrich ; Schumacher, Sonja ; Mueller‐Pfeiffer, Christoph ; Wilhelm, Frank H. ; Athilingam, Jegath ; Moergeli, Hanspeter ; Martin‐Soelch, Chantal</creator><creatorcontrib>Kalebasi, Nilufer ; Kuelen, Eveline ; Schnyder, Ulrich ; Schumacher, Sonja ; Mueller‐Pfeiffer, Christoph ; Wilhelm, Frank H. ; Athilingam, Jegath ; Moergeli, Hanspeter ; Martin‐Soelch, Chantal</creatorcontrib><description>Background
Recent evidence suggests blunted responses to rewarding stimuli in patients with post‐traumatic stress disorder (PTSD). However, it is not clear whether these alterations in reward processing normalize in remitted PTSD patients.
Methods
We tested behavioral and physiological responses to monetary reward in a spatial memory task in 13 accident survivors with remitted PTSD, 14 accident survivors who never had PTSD, and 16 nontrauma‐exposed subjects. All accident survivors were recruited from two samples of severely physically injured patients, who had participated in previous prospective studies on the incidence of PTSD after accidental injury approximately 10 years ago. Reaction time, accuracy, skin conductance responses, and self‐reported mood were assessed during the task.
Results
Accident survivors who never had PTSD and nontrauma exposed controls reported significantly higher positive mood in the reinforced versus nonreinforced condition (P < 0.045 and P < 0.001, respectively), while there was no effect of reinforcement in remitted PTSD subjects.
Conclusions
Our findings suggest an alteration of the reward system in remitted PTSD. Further research is needed to investigate whether altered reward processing is a residual characteristic in PTSD after remission of symptoms or, alternatively, a preexisting risk factor for the development of PTSD after a traumatic event.
Blunted responses to rewarding stimuli were evidenced in patients with posttraumatic stress disorder (PTSD). It is not clear whether these alterations in reward processing normalize in remitted PTSD patients. We showed that accident survivors who never had PTSD and non‐trauma exposed controls reported significantly higher positive mood in the reinforced versus non‐reinforced condition, while there was no effect of reinforcement in remitted PTSD subjects. Our findings suggest an alteration of the reward system in remitted PTSD.</description><identifier>ISSN: 2162-3279</identifier><identifier>EISSN: 2162-3279</identifier><identifier>DOI: 10.1002/brb3.357</identifier><identifier>PMID: 26357590</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Behavior Rating Scale ; Case-Control Studies ; Experimental ; Female ; Fractures ; Humans ; Longitudinal studies ; Male ; Middle Aged ; motivation ; Original Research ; Physiology ; Post traumatic stress disorder ; Prospective Studies ; Psychiatric Status Rating Scales ; psychopathology ; Psychophysiology - methods ; Recovery of Function ; Reinforcement (Psychology) ; remitted ; residual symptoms ; Reward ; Spatial Memory ; Stress Disorders, Post-Traumatic - psychology ; Stress Disorders, Post-Traumatic - therapy ; Trauma</subject><ispartof>Brain and behavior, 2015-08, Vol.5 (8), p.e00357-n/a</ispartof><rights>2015 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2015. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 The Authors. published by Wiley Periodicals, Inc. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5417-c347f2b1ade0e01971b56e563a45907e0303505299cf477320f2ece659d9c7483</citedby><cites>FETCH-LOGICAL-c5417-c347f2b1ade0e01971b56e563a45907e0303505299cf477320f2ece659d9c7483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559020/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559020/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26357590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalebasi, Nilufer</creatorcontrib><creatorcontrib>Kuelen, Eveline</creatorcontrib><creatorcontrib>Schnyder, Ulrich</creatorcontrib><creatorcontrib>Schumacher, Sonja</creatorcontrib><creatorcontrib>Mueller‐Pfeiffer, Christoph</creatorcontrib><creatorcontrib>Wilhelm, Frank H.</creatorcontrib><creatorcontrib>Athilingam, Jegath</creatorcontrib><creatorcontrib>Moergeli, Hanspeter</creatorcontrib><creatorcontrib>Martin‐Soelch, Chantal</creatorcontrib><title>Blunted responses to reward in remitted post‐traumatic stress disorder</title><title>Brain and behavior</title><addtitle>Brain Behav</addtitle><description>Background
Recent evidence suggests blunted responses to rewarding stimuli in patients with post‐traumatic stress disorder (PTSD). However, it is not clear whether these alterations in reward processing normalize in remitted PTSD patients.
Methods
We tested behavioral and physiological responses to monetary reward in a spatial memory task in 13 accident survivors with remitted PTSD, 14 accident survivors who never had PTSD, and 16 nontrauma‐exposed subjects. All accident survivors were recruited from two samples of severely physically injured patients, who had participated in previous prospective studies on the incidence of PTSD after accidental injury approximately 10 years ago. Reaction time, accuracy, skin conductance responses, and self‐reported mood were assessed during the task.
Results
Accident survivors who never had PTSD and nontrauma exposed controls reported significantly higher positive mood in the reinforced versus nonreinforced condition (P < 0.045 and P < 0.001, respectively), while there was no effect of reinforcement in remitted PTSD subjects.
Conclusions
Our findings suggest an alteration of the reward system in remitted PTSD. Further research is needed to investigate whether altered reward processing is a residual characteristic in PTSD after remission of symptoms or, alternatively, a preexisting risk factor for the development of PTSD after a traumatic event.
Blunted responses to rewarding stimuli were evidenced in patients with posttraumatic stress disorder (PTSD). It is not clear whether these alterations in reward processing normalize in remitted PTSD patients. We showed that accident survivors who never had PTSD and non‐trauma exposed controls reported significantly higher positive mood in the reinforced versus non‐reinforced condition, while there was no effect of reinforcement in remitted PTSD subjects. Our findings suggest an alteration of the reward system in remitted PTSD.</description><subject>Behavior Rating Scale</subject><subject>Case-Control Studies</subject><subject>Experimental</subject><subject>Female</subject><subject>Fractures</subject><subject>Humans</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>motivation</subject><subject>Original Research</subject><subject>Physiology</subject><subject>Post traumatic stress disorder</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales</subject><subject>psychopathology</subject><subject>Psychophysiology - methods</subject><subject>Recovery of Function</subject><subject>Reinforcement (Psychology)</subject><subject>remitted</subject><subject>residual symptoms</subject><subject>Reward</subject><subject>Spatial Memory</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Stress Disorders, Post-Traumatic - therapy</subject><subject>Trauma</subject><issn>2162-3279</issn><issn>2162-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc1KxDAUhYMoKjrgE0jBjZuO-W2mG8ER_2BAEF2HNL3VDG0zJq3izkfwGX0SUxyHUTCb3HC_nHuSg9ABwWOCMT0pfMHGTMgNtEtJRlNGZb65Vu-gUQhzHJcgnHK8jXZoFnmR4110Pa37toMy8RAWrg0Qks7Fw6v2ZWLbWDW2G_oLF7rP94_O677RnTVJ6OKVkJQ2OF-C30dbla4DjJb7Hnq4vLg_v05nt1c352ez1AhOZGoYlxUtiC4BAya5JIXIQGRM8-hHAmaYCSxonpuKS8korigYyERe5kbyCdtDp9-6i75ooDTQRku1WnjbaP-mnLbqd6e1T-rRvSgu4gCKo8DxUsC75x5CpxobDNS1bsH1QRFJiOCCZyKiR3_Quet9G5-nKJ1MGKUsWlwJGu9C8FCtzBCshoTUkJCKPx7Rw3XzK_Anjwik38CrreHtXyE1vZuyQfALH2eaZQ</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Kalebasi, Nilufer</creator><creator>Kuelen, Eveline</creator><creator>Schnyder, Ulrich</creator><creator>Schumacher, Sonja</creator><creator>Mueller‐Pfeiffer, Christoph</creator><creator>Wilhelm, Frank H.</creator><creator>Athilingam, Jegath</creator><creator>Moergeli, Hanspeter</creator><creator>Martin‐Soelch, Chantal</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons, Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201508</creationdate><title>Blunted responses to reward in remitted post‐traumatic stress disorder</title><author>Kalebasi, Nilufer ; Kuelen, Eveline ; Schnyder, Ulrich ; Schumacher, Sonja ; Mueller‐Pfeiffer, Christoph ; Wilhelm, Frank H. ; Athilingam, Jegath ; Moergeli, Hanspeter ; Martin‐Soelch, Chantal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5417-c347f2b1ade0e01971b56e563a45907e0303505299cf477320f2ece659d9c7483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Behavior Rating Scale</topic><topic>Case-Control Studies</topic><topic>Experimental</topic><topic>Female</topic><topic>Fractures</topic><topic>Humans</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>motivation</topic><topic>Original Research</topic><topic>Physiology</topic><topic>Post traumatic stress disorder</topic><topic>Prospective Studies</topic><topic>Psychiatric Status Rating Scales</topic><topic>psychopathology</topic><topic>Psychophysiology - methods</topic><topic>Recovery of Function</topic><topic>Reinforcement (Psychology)</topic><topic>remitted</topic><topic>residual symptoms</topic><topic>Reward</topic><topic>Spatial Memory</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Stress Disorders, Post-Traumatic - therapy</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalebasi, Nilufer</creatorcontrib><creatorcontrib>Kuelen, Eveline</creatorcontrib><creatorcontrib>Schnyder, Ulrich</creatorcontrib><creatorcontrib>Schumacher, Sonja</creatorcontrib><creatorcontrib>Mueller‐Pfeiffer, Christoph</creatorcontrib><creatorcontrib>Wilhelm, Frank H.</creatorcontrib><creatorcontrib>Athilingam, Jegath</creatorcontrib><creatorcontrib>Moergeli, Hanspeter</creatorcontrib><creatorcontrib>Martin‐Soelch, Chantal</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalebasi, Nilufer</au><au>Kuelen, Eveline</au><au>Schnyder, Ulrich</au><au>Schumacher, Sonja</au><au>Mueller‐Pfeiffer, Christoph</au><au>Wilhelm, Frank H.</au><au>Athilingam, Jegath</au><au>Moergeli, Hanspeter</au><au>Martin‐Soelch, Chantal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blunted responses to reward in remitted post‐traumatic stress disorder</atitle><jtitle>Brain and behavior</jtitle><addtitle>Brain Behav</addtitle><date>2015-08</date><risdate>2015</risdate><volume>5</volume><issue>8</issue><spage>e00357</spage><epage>n/a</epage><pages>e00357-n/a</pages><issn>2162-3279</issn><eissn>2162-3279</eissn><abstract>Background
Recent evidence suggests blunted responses to rewarding stimuli in patients with post‐traumatic stress disorder (PTSD). However, it is not clear whether these alterations in reward processing normalize in remitted PTSD patients.
Methods
We tested behavioral and physiological responses to monetary reward in a spatial memory task in 13 accident survivors with remitted PTSD, 14 accident survivors who never had PTSD, and 16 nontrauma‐exposed subjects. All accident survivors were recruited from two samples of severely physically injured patients, who had participated in previous prospective studies on the incidence of PTSD after accidental injury approximately 10 years ago. Reaction time, accuracy, skin conductance responses, and self‐reported mood were assessed during the task.
Results
Accident survivors who never had PTSD and nontrauma exposed controls reported significantly higher positive mood in the reinforced versus nonreinforced condition (P < 0.045 and P < 0.001, respectively), while there was no effect of reinforcement in remitted PTSD subjects.
Conclusions
Our findings suggest an alteration of the reward system in remitted PTSD. Further research is needed to investigate whether altered reward processing is a residual characteristic in PTSD after remission of symptoms or, alternatively, a preexisting risk factor for the development of PTSD after a traumatic event.
Blunted responses to rewarding stimuli were evidenced in patients with posttraumatic stress disorder (PTSD). It is not clear whether these alterations in reward processing normalize in remitted PTSD patients. We showed that accident survivors who never had PTSD and non‐trauma exposed controls reported significantly higher positive mood in the reinforced versus non‐reinforced condition, while there was no effect of reinforcement in remitted PTSD subjects. Our findings suggest an alteration of the reward system in remitted PTSD.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>26357590</pmid><doi>10.1002/brb3.357</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Behavior Rating Scale Case-Control Studies Experimental Female Fractures Humans Longitudinal studies Male Middle Aged motivation Original Research Physiology Post traumatic stress disorder Prospective Studies Psychiatric Status Rating Scales psychopathology Psychophysiology - methods Recovery of Function Reinforcement (Psychology) remitted residual symptoms Reward Spatial Memory Stress Disorders, Post-Traumatic - psychology Stress Disorders, Post-Traumatic - therapy Trauma |
| title | Blunted responses to reward in remitted post‐traumatic stress disorder |
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