The Wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster

The Drosophila sex determination hierarchy is a classic example of a transcriptional regulatory hierarchy, with sex-specific isoforms regulating morphology and behavior. We use a structural equation modeling approach, leveraging natural genetic variation from two studies on Drosophila female head ti...

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Veröffentlicht in:	BMC systems biology 2015-09, Vol.9 (1), p.53-53, Article 53
Hauptverfasser:	Fear, Justin M, Arbeitman, Michelle N, Salomon, Matthew P, Dalton, Justin E, Tower, John, Nuzhdin, Sergey V, McIntyre, Lauren M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Computational Biology - methods DNA-Binding Proteins - genetics Drosophila Drosophila melanogaster - genetics Drosophila Proteins - genetics Female Gene Regulatory Networks Genetic aspects Male Models, Genetic Nuclear Proteins - genetics Physiological aspects RNA, Messenger - genetics RNA, Messenger - metabolism Sex Determination Processes - genetics Supervised Machine Learning Unsupervised Machine Learning
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