Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells

Herein we show that a majority of human brain tumor samples and cell lines over-expressed cannabinoid receptor CB1 as compared to normal human astrocytes (NHA), while uniformly expressed low levels of CB2. This finding prompted us to investigate the therapeutic exploitation of CB1 inactivation by SR...

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Veröffentlicht in:	Oncotarget 2015-06, Vol.6 (17), p.15464-15481
Hauptverfasser:	Ciaglia, Elena, Torelli, Giovanni, Pisanti, Simona, Picardi, Paola, D'Alessandro, Alba, Laezza, Chiara, Malfitano, Anna Maria, Fiore, Donatella, Pagano Zottola, Antonio Christian, Proto, Maria Chiara, Catapano, Giuseppe, Gazzerro, Patrizia, Bifulco, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Astrocytes - metabolism Brain Neoplasms - drug therapy Brain Neoplasms - immunology Brain Neoplasms - pathology Cell Line, Tumor G1 Phase Cell Cycle Checkpoints - drug effects Glioma - drug therapy Glioma - immunology Glioma - pathology Histocompatibility Antigens Class I - biosynthesis Humans Killer Cells, Natural - immunology Mice Mice, Nude Piperidines - pharmacology Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - biosynthesis Receptor, Cannabinoid, CB1 - genetics Research Paper RNA Interference RNA, Small Interfering STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Transforming Growth Factor beta1 - secretion Xenograft Model Antitumor Assays
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