Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

The most abundant populations of non-neoplastic cells in the glioblastoma (GBM) microenvironment are resident microglia, macrophages and infiltrating monocytes from the blood circulation. The mechanisms by which monocytes infiltrate into GBM, their fate following infiltration, and their role in GBM...

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Veröffentlicht in:	Oncotarget 2015-06, Vol.6 (17), p.15077-15094
Hauptverfasser:	Feng, Xi, Szulzewsky, Frank, Yerevanian, Alexan, Chen, Zhihong, Heinzmann, David, Rasmussen, Rikke Darling, Alvarez-Garcia, Virginia, Kim, Yeonghwan, Wang, Bingcheng, Tamagno, Ilaria, Zhou, Hao, Li, Xiaoxia, Kettenmann, Helmut, Ransohoff, Richard M, Hambardzumyan, Dolores
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line CX3C Chemokine Receptor 1 Female Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Humans Immunoblotting Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-1beta - pharmacology Macrophages - metabolism Macrophages - pathology Male Mice, Knockout Mice, Transgenic Microglia - metabolism Microglia - pathology Microscopy, Confocal Monocytes - metabolism Monocytes - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Receptors, Interleukin-1 Type I - genetics Receptors, Interleukin-1 Type I - metabolism Research Paper Reverse Transcriptase Polymerase Chain Reaction Survival Analysis Tumor Cells, Cultured Tumor Microenvironment - genetics
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