Phage protein-targeted cancer nanomedicines

Nanoencapsulation of anticancer drugs improves their therapeutic indices by virtue of the enhanced permeation and retention effect which achieves passive targeting of nanoparticles in tumors. This effect can be significantly enhanced by active targeting of nanovehicles to tumors. Numerous ligands ha...

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Veröffentlicht in:	FEBS letters 2014-01, Vol.588 (2), p.341-349
Hauptverfasser:	Petrenko, V.A., Jayanna, P.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-dioleoyl-3-trimethylammonium-propane 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)2000] Animals antibodies antineoplastic agents Bacteriophages cell-penetrating peptides CHOL cholesterol CPP diphenylhexatriene DOTAP DPH DPPG Drug Delivery Systems ePC FET fluorescence energy transfer Humans Landscape phage landscapes ligand-mediated targeting ligands LMT Major coat protein manufacturing Molecular Targeted Therapy - methods nanocapsules Nanomedicine Nanomedicine - methods nanoparticles neoplasms Neoplasms - drug therapy PEG PEG2K-PE peptide libraries Phage display phosphatidylcholine (egg) polyethylene glycol siRNA small interfering RNA Targeted drug delivery trans-membrane Viral Proteins - chemistry Viral Proteins - metabolism
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