Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis

Autophagy is a major catabolic process responsible for the delivery of proteins and organelles to the lysosome/vacuole for degradation. Malfunction of this pathway has been implicated in numerous pathological conditions. Different organelles have been found to contribute to the formation of autophag...

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Veröffentlicht in:	The EMBO journal 2015-08, Vol.34 (16), p.2117-2131
Hauptverfasser:	Shpilka, Tomer, Welter, Evelyn, Borovsky, Noam, Amar, Nira, Mari, Muriel, Reggiori, Fulvio, Elazar, Zvulun
Format:	Artikel
Sprache:	eng
Schlagworte:	Atg8 autophagosome biogenesis Autophagy Biosynthesis EMBO07 EMBO21 Enzymes Esters Esters - metabolism fatty acid synthase lipid droplets Lipid Droplets - metabolism Lipids Metabolic Networks and Pathways - genetics Nitrogen Phagosomes - metabolism Proteins Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Triglycerides - metabolism Yeasts
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