Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin

Heparin is the most widely used anticoagulant drug in the world today. Heparin is currently produced from animal tissues, primarily porcine intestines. A recent contamination crisis motivated development of a non‐animal‐derived source of this critical drug. We hypothesized that Chinese hamster ovary...

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Veröffentlicht in:	Biotechnology journal 2015-07, Vol.10 (7), p.1067-1081
Hauptverfasser:	Baik, Jong Youn, Dahodwala, Hussain, Oduah, Eziafa, Talman, Lee, Gemmill, Trent R., Gasimli, Leyla, Datta, Payel, Yang, Bo, Li, Guoyun, Zhang, Fuming, Li, Lingyun, Linhardt, Robert J., Campbell, Andrew M., Gorfien, Stephen F., Sharfstein, Susan T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants Bioreactors Biosynthetic Pathways CHO Cells Cricetinae Cricetulus Disaccharide analysis Fed-batch cultures Glycosaminoglycans Heparin - biosynthesis Heparin - metabolism Metabolic Engineering
Online-Zugang:	Volltext
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