Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation

Galectin-1 (Gal-1) is a β-galactoside-binding protein with diverse biological activities in the pathogenesis of inflammation but has been poorly investigated in terms of ocular inflammation. In the present study, we monitored the anti-inflammatory effects of Gal-1 using the in vivo rodent model of e...

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Veröffentlicht in:	Molecular vision 2015-09, Vol.21, p.1036-1050
Hauptverfasser:	Zanon, Caroline de Freitas, Sonehara, Nathália Martins, Girol, Ana Paula, Gil, Cristiane Damas, Oliani, Sonia Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - immunology Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cell Line Chemokine CCL2 - antagonists & inhibitors Chemokine CCL2 - genetics Chemokine CCL2 - immunology Cyclooxygenase 2 - genetics Cyclooxygenase 2 - immunology Dexamethasone - pharmacology Disease Models, Animal Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Galectin 1 - genetics Galectin 1 - immunology Galectin 1 - pharmacology Gene Expression Regulation Humans Injections, Subcutaneous Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-6 - antagonists & inhibitors Interleukin-6 - genetics Interleukin-6 - immunology Lipopolysaccharides Neutrophil Infiltration - drug effects Rats Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - pharmacology Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Uveitis - chemically induced Uveitis - drug therapy Uveitis - genetics Uveitis - immunology
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