In vitro antiretroviral activity and in vivo toxicity of the potential topical microbicide copper phthalocyanine sulfate

Copper has antimicrobial properties and has been studied for its activity against viruses, including HIV. Copper complexed within a phthalocyanine ring, forming copper (II) phthalocyanine sulfate (CuPcS), may have a role in microbicide development when used intravaginally. CuPcS toxicity was tested...

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Veröffentlicht in:	Virology journal 2015-08, Vol.12 (1), p.132-132, Article 132
Hauptverfasser:	Styczynski, Ashley R, Anwar, Khandaker N, Sultana, Habiba, Ghanem, Abdelhamid, Lurain, Nell, Chua, Aishi, Ghassemi, Mahmood, Novak, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravaginal Analysis Animals Anti-Infective Agents, Local - adverse effects Anti-Infective Agents, Local - pharmacology Antiviral agents Cell Survival - drug effects Cells, Cultured Complications and side effects Copper compounds Disease Transmission, Infectious - prevention & control Dosage and administration Dose-Response Relationship, Drug Female Health aspects HIV (Viruses) HIV infection HIV Infections - prevention & control HIV Infections - transmission Humans Indoles - adverse effects Indoles - pharmacology Infection Medical research Medicine, Experimental Mice, Inbred BALB C Models, Biological Molybdenum alloys Organometallic Compounds - adverse effects Organometallic Compounds - pharmacology Phthalocyanins Prevention Sulfates Sulfates - adverse effects Sulfates - pharmacology Treatment Outcome
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