Enhanced differentiation of intraepithelial lymphocytes in the intestine of polymeric immunoglobulin receptor‐deficient mice

Summary To clarify the effect of secretory IgA (sIgA) deficiency on gut homeostasis, we examined intraepithelial lymphocytes (IELs) in the small intestine (SI) of polymeric immunoglobulin receptor‐deficient (pIgR−/−) mice. The pIgR−/− mice exhibited the accumulation of CD8αβ+ T‐cell receptor (TCR)‐α...

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Veröffentlicht in:	Immunology 2015-09, Vol.146 (1), p.59-69
Hauptverfasser:	Kato‐Nagaoka, Noriko, Shimada, Shin‐Ichiro, Yamakawa, Yoko, Tsujibe, Satoshi, Naito, Tomoaki, Setoyama, Hiromi, Watanabe, Yohei, Shida, Kan, Matsumoto, Satoshi, Nanno, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals bone marrow cell Bone Marrow Cells - immunology Bromodeoxyuridine CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Differentiation - immunology Cell Movement - immunology Cells, Cultured Immunoglobulin A, Secretory - genetics Immunoglobulin A, Secretory - immunology Interferon-gamma - biosynthesis Interleukin-17 - biosynthesis Intestinal Mucosa - cytology Intestinal Mucosa - immunology intestinal permeability Intestine, Small - cytology Intestine, Small - immunology intraepithelial lymphocyte Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Original polymeric immunoglobulin receptor Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Polymeric Immunoglobulin - genetics spleen cell Staining and Labeling
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