Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome

The authors report that the ultrastructure and plasticity of excitatory synapses connecting dentate gyrus and CA3 of the hippocampus are severely compromised in a transchromosomic mouse model of Down syndrome. These alterations are accompanied by unstable information coding by CA3 and CA1 place cell...

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Veröffentlicht in:	Nature neuroscience 2015-09, Vol.18 (9), p.1291-1298
Hauptverfasser:	Witton, Jonathan, Padmashri, Ragunathan, Zinyuk, Larissa E, Popov, Victor I, Kraev, Igor, Line, Samantha J, Jensen, Thomas P, Tedoldi, Angelo, Cummings, Damian M, Tybulewicz, Victor L J, Fisher, Elizabeth M C, Bannerman, David M, Randall, Andrew D, Brown, Jonathan T, Edwards, Frances A, Rusakov, Dmitri A, Stewart, Michael G, Jones, Matt W
Format:	Artikel
Sprache:	eng
Schlagworte:	14/69 631/208/366 631/378/1595/1554 631/378/1689 631/378/2629/2630 64/60 9/30 9/74 Animal Genetics and Genomics Animal models in research Animals Behavioral Sciences Biological Techniques Biomedicine CA3 Region, Hippocampal - pathology CA3 Region, Hippocampal - physiopathology Chromosomes Chromosomes, Human, Pair 21 - genetics Cognitive ability Dentate Gyrus - pathology Dentate Gyrus - physiopathology Disease Models, Animal Down syndrome Down Syndrome - genetics Down Syndrome - pathology Down Syndrome - physiopathology Humans Male Maze Learning - physiology Mice Mice, 129 Strain Mice, Inbred C57BL Nerve Net - pathology Nerve Net - physiopathology Neural networks Neurobiology Neurosciences Organ Culture Techniques Physiology Trisomy - genetics University colleges
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