Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro

Neuropeptide Y (NPY) is expressed in mammalian retina but the location and potential modulatory effects of NPY receptor activation remain largely unknown. Retinal ganglion cell (RGC) death is a hallmark of several retinal degenerative diseases, particularly glaucoma. Using purified RGCs and ex vivo...

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Veröffentlicht in:	ASN neuro 2015-07, Vol.7 (4), p.175909141559829
Hauptverfasser:	Martins, João, Elvas, Filipe, Brudzewsky, Dan, Martins, Tânia, Kolomiets, Bogdan, Tralhão, Pedro, Gøtzsche, Casper R., Cavadas, Cláudia, Castelo-Branco, Miguel, Woldbye, David P. D., Picaud, Serge, Santiago, Ana R., Ambrósio, António F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Calcium - metabolism Cells, Cultured Disease Models, Animal Electroretinography Gene Expression Regulation - drug effects Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics In Situ Nick-End Labeling Life Sciences Male Neurons and Cognition Neuropeptide Y - agonists Neuropeptide Y - analogs & derivatives Neuropeptide Y - antagonists & inhibitors Neuropeptide Y - genetics Neuropeptide Y - metabolism Neuropeptide Y - pharmacology Original Peptide Fragments - pharmacology Protein Binding - drug effects Rats Rats, Long-Evans Rats, Wistar Receptors, Neuropeptide Y - agonists Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism Retinal Diseases - pathology Retinal Diseases - physiopathology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism RNA, Messenger - metabolism Sulfur Isotopes - pharmacokinetics Transcription Factor Brn-3A - metabolism
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