ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation

ΔNp63 is required for both the proliferation and differentiation of keratinocytes, but its role in the differentiation of these cells is poorly understood. The corresponding gene, TP63, harbors the MIR944 sequence within its intron. However, the mechanism of biogenesis and the function of miR-944 ar...

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Veröffentlicht in:	Nucleic acids research 2015-09, Vol.43 (15), p.7462-7479
Hauptverfasser:	Kim, Kyu-Han, Cho, Eun-Gyung, Yu, Seok Jong, Kang, Hyojin, Kim, Yoon-Jin, Kim, Sang Hoon, Lee, Tae Ryong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - genetics Cells, Cultured Epidermis - cytology Gene Expression Regulation Humans Introns Keratinocytes - metabolism MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - metabolism Molecular Biology Promoter Regions, Genetic Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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