Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

Chemokine receptors belong to the class of G protein-coupled receptors and are important in the host defense against infections and inflammation. However, aberrant chemokine signaling is linked to different disorders such as cancer, central nervous system and immune disorders, and viral infections [...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2015-09, Vol.407 (23), p.7067-7081
Hauptverfasser:	Mladic, Marija, Scholten, Danny J, Wijtmans, Maikel, Falck, David, Leurs, Rob, Niessen, Wilfried M. A, Smit, Martine J, Kool, Jeroen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Analytical methods Assessments Biochemistry Biological activity Candidates Central nervous system Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chemokine receptors Chemokines Chemokines - chemistry Chemokines - metabolism Chromatography Chromatography, High Pressure Liquid - methods CXCR3 receptor Drugs Food Science HEK293 Cells Histamine Humans Identification immune system inflammation Laboratory Medicine Ligands Liquid chromatography Mass spectrometry Mathematical analysis Metabolism Metabolites metabolomics Monitoring/Environmental Analysis Nanostructure Optimization Pharmaceutical industry Pharmacodynamics pharmacology Profiling Protein Interaction Mapping - methods Proteins Receptors, CXCR3 - chemistry Receptors, CXCR3 - metabolism Reproducibility of Results Research Paper Scientific imaging Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Toxicity
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