Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis

Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description in rheumatoid synovium. However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains broadly unknown. We aimed to study the presence and characteris...

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Veröffentlicht in:	BMC musculoskeletal disorders 2015-08, Vol.16 (1), p.226-226, Article 226
Hauptverfasser:	Prieto-Potin, Iván, Largo, Raquel, Roman-Blas, Jorge A, Herrero-Beaumont, Gabriel, Walsh, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - analysis Aged Angiogenesis Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - pathology Biomarkers Bone marrow Calcium - therapeutic use Cartilage Cathepsin K - analysis Cross-Sectional Studies Diphosphonates - therapeutic use Disease Female Foreign bodies Giant Cells - chemistry Giant Cells - ultrastructure Giant Cells, Langhans - chemistry Giant Cells, Langhans - ultrastructure Glucocorticoids - therapeutic use Humans Inflammation Isoenzymes - analysis Knee Knee Joint - pathology Macrophages Macrophages - chemistry Macrophages - classification Macrophages - ultrastructure Male Middle Aged Musculoskeletal diseases Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - pathology Osteoclasts - chemistry Osteoclasts - ultrastructure Pathology Phosphatase Research Design Rheumatoid arthritis Rheumatology Single-Blind Method Synovial Membrane - pathology Tartrate-Resistant Acid Phosphatase Tibia - pathology Vitamin D - therapeutic use
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