Oestrogen-mediated phosphorylation and stabilization of BRCA2 protein in breast

Disease-associated BRCA2 mutations typically result in protein truncations that delete the phosphorylation-regulated S3291 BRCA2 domain that interacts with Rad51. BRCA2 hereditary breast cancers are usually ER⁺, differing from BRCA1 hereditary cancers, which are usually ER⁻. We studied BRCA2 protein...

Ausführliche Beschreibung