High‐density lipoprotein inhibits mechanical stress‐induced cardiomyocyte autophagy and cardiac hypertrophy through angiotensin II type 1 receptor‐mediated PI3K/Akt pathway

Mechanical stress triggers cardiac hypertrophy and autophagy through an angiotensin II (Ang II) type 1 (AT1) receptor‐dependent mechanism. Low level of high density lipoprotein (HDL) is an independent risk factor for cardiac hypertrophy. This study was designed to evaluate the effect of HDL on mecha...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2015-08, Vol.19 (8), p.1929-1938
Hauptverfasser:	Lin, Li, Liu, Xuebo, Xu, Jianfeng, Weng, Liqing, Ren, Jun, Ge, Junbo, Zou, Yunzeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AT1 receptor autophagy Autophagy - drug effects cardiac hypertrophy Cardiomegaly - pathology Cardiotonic Agents - pharmacology Cells, Cultured Down-Regulation - drug effects HDL heart failure Lipoproteins, HDL - pharmacology Male Mice, Inbred C57BL Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Original Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 - metabolism Signal Transduction - drug effects Stress, Mechanical
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