Medullary circuits for nociceptive modulation

Highlights ► Opioid analgesia depends on descending modulation from the medullary raphe. ► Opioids produce analgesia without altering the tonic discharge of medullary neurons. ► Normally, phasic neuronal responses of brainstem cells facilitate nociception. ► Morphine produces analgesia by blocking t...

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Veröffentlicht in:	Current opinion in neurobiology 2012-08, Vol.22 (4), p.640-645
1. Verfasser:	Mason, Peggy
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - physiology Analgesics, Opioid - pharmacology Animals Humans Medulla Oblongata - cytology Morphine - pharmacology Nerve Net - physiology Neurology Nociceptors - drug effects Nociceptors - physiology Psychiatry Rats
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Zusammenfassung:	Highlights ► Opioid analgesia depends on descending modulation from the medullary raphe. ► Opioids produce analgesia without altering the tonic discharge of medullary neurons. ► Normally, phasic neuronal responses of brainstem cells facilitate nociception. ► Morphine produces analgesia by blocking the phasic responses of brainstem cells. ► Brainstem cells may modulate non-nociceptive functions during pain-free periods.
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2012.03.008