CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability

The CCR4-NOT deadenylase complex plays crucial roles in mRNA decay and translational repression induced by poly(A) tail shortening. Although the in vitro activities of each component of this complex have been well characterized, its in vivo role in immune cells remains unclear. Here we show that mic...

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Veröffentlicht in:	The Journal of experimental medicine 2015-08, Vol.212 (9), p.1465-1479
Hauptverfasser:	Inoue, Takeshi, Morita, Masahiro, Hijikata, Atsushi, Fukuda-Yuzawa, Yoko, Adachi, Shungo, Isono, Kyoichi, Ikawa, Tomokatsu, Kawamoto, Hiroshi, Koseki, Haruhiko, Natsume, Tohru, Fukao, Taro, Ohara, Osamu, Yamamoto, Tadashi, Kurosaki, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - immunology Cell Differentiation - genetics Cell Differentiation - immunology Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics Gene Rearrangement, B-Lymphocyte, Heavy Chain - immunology Mice Mice, Transgenic RNA Stability - genetics RNA Stability - immunology RNA, Messenger - genetics RNA, Messenger - immunology Transcription Factors - genetics Transcription Factors - immunology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - immunology
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