Advanced Oxidation Protein Products as a Novel Marker of Oxidative Stress in Postmenopausal Osteoporosis
Advanced oxidation protein products (AOPPs) are acknowledged as a novel marker of oxidation-mediated protein damage. This study aimed to investigate the plasma levels of AOPPs in postmenopausal osteoporotic women, and to determine the relationship between AOPPs accumulation and lumbar bone mineral d...
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| Veröffentlicht in: | Medical science monitor 2015-08, Vol.21, p.2428-2432 |
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| creator | Wu, Qian Zhong, Zhao-Ming Pan, Ying Zeng, Ji-Huan Zheng, Shuai Zhu, Si-Yuan Chen, Jian-Ting |
| description | Advanced oxidation protein products (AOPPs) are acknowledged as a novel marker of oxidation-mediated protein damage. This study aimed to investigate the plasma levels of AOPPs in postmenopausal osteoporotic women, and to determine the relationship between AOPPs accumulation and lumbar bone mineral destiny (BMD) or bone turnover markers.
Lumbar BMD was measured by dual-energy X-ray absorptiometry. Plasma AOPPs levels as a marker of protein oxidation damage and malondialdehyde (MDA) levels as a marker of lipid peroxidation were measured by spectrophotometry. The concentrations of 2 specific markers of bone turnover, bone-specific alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase5b, (TRACP 5b) were quantified using ELISA kits.
We recruited 60 postmenopausal women meeting osteoporosis (OP) diagnostic criteria of World Health Organization (WHO) and 60 postmenopausal women without OP. Plasma levels of AOPPs (P |
| doi_str_mv | 10.12659/msm.894347 |
| format | Article |
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Lumbar BMD was measured by dual-energy X-ray absorptiometry. Plasma AOPPs levels as a marker of protein oxidation damage and malondialdehyde (MDA) levels as a marker of lipid peroxidation were measured by spectrophotometry. The concentrations of 2 specific markers of bone turnover, bone-specific alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase5b, (TRACP 5b) were quantified using ELISA kits.
We recruited 60 postmenopausal women meeting osteoporosis (OP) diagnostic criteria of World Health Organization (WHO) and 60 postmenopausal women without OP. Plasma levels of AOPPs (P<0.001), BALP (P<0.001) and TRACP 5b (P<0.001) were statistically significantly increased in the postmenopausal osteoporotic women compared with controls, but there was no statistically significant difference in MDA (P=0.124) between the 2 groups. Plasma AOPPs levels were negatively correlated with lumbar BMD and positively correlated with bone turnover markers both in postmenopausal osteoporotic women and in all subjects. However, plasma MDA levels were not correlated with lumbar BMD or bone turnover markers.
In postmenopausal osteoporotic women elevated AOPPs is associated with reduced BMD and increased bone turnover markers. Because AOPPs is stable and easy to detect it may be used as a simple plasma marker to predict the severity of postmenopausal OP.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/msm.894347</identifier><identifier>PMID: 26286507</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Acid Phosphatase - blood ; Advanced Oxidation Protein Products - blood ; Aged ; Alkaline Phosphatase - blood ; Biomarkers - blood ; Bone Density ; Bone Remodeling ; Case-Control Studies ; Clinical Research ; Female ; Humans ; Isoenzymes - blood ; Lumbar Vertebrae ; Middle Aged ; Osteoporosis, Postmenopausal - blood ; Osteoporosis, Postmenopausal - physiopathology ; Oxidative Stress ; Tartrate-Resistant Acid Phosphatase</subject><ispartof>Medical science monitor, 2015-08, Vol.21, p.2428-2432</ispartof><rights>Med Sci Monit, 2015 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-4fe404fec8dfddf7dae472a7da9cc4db7f508367b3aa22d26b378dbb085630db3</citedby><cites>FETCH-LOGICAL-c447t-4fe404fec8dfddf7dae472a7da9cc4db7f508367b3aa22d26b378dbb085630db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547543/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547543/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26286507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Qian</creatorcontrib><creatorcontrib>Zhong, Zhao-Ming</creatorcontrib><creatorcontrib>Pan, Ying</creatorcontrib><creatorcontrib>Zeng, Ji-Huan</creatorcontrib><creatorcontrib>Zheng, Shuai</creatorcontrib><creatorcontrib>Zhu, Si-Yuan</creatorcontrib><creatorcontrib>Chen, Jian-Ting</creatorcontrib><title>Advanced Oxidation Protein Products as a Novel Marker of Oxidative Stress in Postmenopausal Osteoporosis</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>Advanced oxidation protein products (AOPPs) are acknowledged as a novel marker of oxidation-mediated protein damage. This study aimed to investigate the plasma levels of AOPPs in postmenopausal osteoporotic women, and to determine the relationship between AOPPs accumulation and lumbar bone mineral destiny (BMD) or bone turnover markers.
Lumbar BMD was measured by dual-energy X-ray absorptiometry. Plasma AOPPs levels as a marker of protein oxidation damage and malondialdehyde (MDA) levels as a marker of lipid peroxidation were measured by spectrophotometry. The concentrations of 2 specific markers of bone turnover, bone-specific alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase5b, (TRACP 5b) were quantified using ELISA kits.
We recruited 60 postmenopausal women meeting osteoporosis (OP) diagnostic criteria of World Health Organization (WHO) and 60 postmenopausal women without OP. Plasma levels of AOPPs (P<0.001), BALP (P<0.001) and TRACP 5b (P<0.001) were statistically significantly increased in the postmenopausal osteoporotic women compared with controls, but there was no statistically significant difference in MDA (P=0.124) between the 2 groups. Plasma AOPPs levels were negatively correlated with lumbar BMD and positively correlated with bone turnover markers both in postmenopausal osteoporotic women and in all subjects. However, plasma MDA levels were not correlated with lumbar BMD or bone turnover markers.
In postmenopausal osteoporotic women elevated AOPPs is associated with reduced BMD and increased bone turnover markers. Because AOPPs is stable and easy to detect it may be used as a simple plasma marker to predict the severity of postmenopausal OP.</description><subject>Acid Phosphatase - blood</subject><subject>Advanced Oxidation Protein Products - blood</subject><subject>Aged</subject><subject>Alkaline Phosphatase - blood</subject><subject>Biomarkers - blood</subject><subject>Bone Density</subject><subject>Bone Remodeling</subject><subject>Case-Control Studies</subject><subject>Clinical Research</subject><subject>Female</subject><subject>Humans</subject><subject>Isoenzymes - blood</subject><subject>Lumbar Vertebrae</subject><subject>Middle Aged</subject><subject>Osteoporosis, Postmenopausal - blood</subject><subject>Osteoporosis, Postmenopausal - physiopathology</subject><subject>Oxidative Stress</subject><subject>Tartrate-Resistant Acid Phosphatase</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd1LwzAUxYMoTqdPvkseBdlMm6TpXoQx_ILNCdPnkCa3rto2M0mH_vfWfTEh5FzIL-fey0HoIiL9KE744KbyVT8dMMrEATqJEkZ7VHByuFd30Kn3H4TEaUL4MerESVtxIk7QfGiWqtZg8PS7MCoUtsYvzgYoVmoaHTxW7cHPdgklnij3CQ7bfMsvAc-CA-_x3w_rQwW1XajGqxJPfQC7sM76wp-ho1yVHs432kVv93evo8feePrwNBqOe5oxEXosB0baS6cmNyYXRgETsWp1oDUzmcg5SWkiMqpUHJs4yahITZaRlCeUmIx20e3ad9FkFRgNdXCqlAtXVMr9SKsK-f-lLuby3S4l40xwRluDq42Bs18N-CCrwmsoS1WDbbyMBOGCcpKkLXq9RnW7oneQ79pERK6ykZPZRK6zaenL_cl27DYM-gvIg431</recordid><startdate>20150818</startdate><enddate>20150818</enddate><creator>Wu, Qian</creator><creator>Zhong, Zhao-Ming</creator><creator>Pan, Ying</creator><creator>Zeng, Ji-Huan</creator><creator>Zheng, Shuai</creator><creator>Zhu, Si-Yuan</creator><creator>Chen, Jian-Ting</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150818</creationdate><title>Advanced Oxidation Protein Products as a Novel Marker of Oxidative Stress in Postmenopausal Osteoporosis</title><author>Wu, Qian ; Zhong, Zhao-Ming ; Pan, Ying ; Zeng, Ji-Huan ; Zheng, Shuai ; Zhu, Si-Yuan ; Chen, Jian-Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-4fe404fec8dfddf7dae472a7da9cc4db7f508367b3aa22d26b378dbb085630db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acid Phosphatase - blood</topic><topic>Advanced Oxidation Protein Products - blood</topic><topic>Aged</topic><topic>Alkaline Phosphatase - blood</topic><topic>Biomarkers - blood</topic><topic>Bone Density</topic><topic>Bone Remodeling</topic><topic>Case-Control Studies</topic><topic>Clinical Research</topic><topic>Female</topic><topic>Humans</topic><topic>Isoenzymes - blood</topic><topic>Lumbar Vertebrae</topic><topic>Middle Aged</topic><topic>Osteoporosis, Postmenopausal - blood</topic><topic>Osteoporosis, Postmenopausal - physiopathology</topic><topic>Oxidative Stress</topic><topic>Tartrate-Resistant Acid Phosphatase</topic><toplevel>online_resources</toplevel><creatorcontrib>Wu, Qian</creatorcontrib><creatorcontrib>Zhong, Zhao-Ming</creatorcontrib><creatorcontrib>Pan, Ying</creatorcontrib><creatorcontrib>Zeng, Ji-Huan</creatorcontrib><creatorcontrib>Zheng, Shuai</creatorcontrib><creatorcontrib>Zhu, Si-Yuan</creatorcontrib><creatorcontrib>Chen, Jian-Ting</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Qian</au><au>Zhong, Zhao-Ming</au><au>Pan, Ying</au><au>Zeng, Ji-Huan</au><au>Zheng, Shuai</au><au>Zhu, Si-Yuan</au><au>Chen, Jian-Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced Oxidation Protein Products as a Novel Marker of Oxidative Stress in Postmenopausal Osteoporosis</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2015-08-18</date><risdate>2015</risdate><volume>21</volume><spage>2428</spage><epage>2432</epage><pages>2428-2432</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>Advanced oxidation protein products (AOPPs) are acknowledged as a novel marker of oxidation-mediated protein damage. This study aimed to investigate the plasma levels of AOPPs in postmenopausal osteoporotic women, and to determine the relationship between AOPPs accumulation and lumbar bone mineral destiny (BMD) or bone turnover markers.
Lumbar BMD was measured by dual-energy X-ray absorptiometry. Plasma AOPPs levels as a marker of protein oxidation damage and malondialdehyde (MDA) levels as a marker of lipid peroxidation were measured by spectrophotometry. The concentrations of 2 specific markers of bone turnover, bone-specific alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase5b, (TRACP 5b) were quantified using ELISA kits.
We recruited 60 postmenopausal women meeting osteoporosis (OP) diagnostic criteria of World Health Organization (WHO) and 60 postmenopausal women without OP. Plasma levels of AOPPs (P<0.001), BALP (P<0.001) and TRACP 5b (P<0.001) were statistically significantly increased in the postmenopausal osteoporotic women compared with controls, but there was no statistically significant difference in MDA (P=0.124) between the 2 groups. Plasma AOPPs levels were negatively correlated with lumbar BMD and positively correlated with bone turnover markers both in postmenopausal osteoporotic women and in all subjects. However, plasma MDA levels were not correlated with lumbar BMD or bone turnover markers.
In postmenopausal osteoporotic women elevated AOPPs is associated with reduced BMD and increased bone turnover markers. Because AOPPs is stable and easy to detect it may be used as a simple plasma marker to predict the severity of postmenopausal OP.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>26286507</pmid><doi>10.12659/msm.894347</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acid Phosphatase - blood Advanced Oxidation Protein Products - blood Aged Alkaline Phosphatase - blood Biomarkers - blood Bone Density Bone Remodeling Case-Control Studies Clinical Research Female Humans Isoenzymes - blood Lumbar Vertebrae Middle Aged Osteoporosis, Postmenopausal - blood Osteoporosis, Postmenopausal - physiopathology Oxidative Stress Tartrate-Resistant Acid Phosphatase |
| title | Advanced Oxidation Protein Products as a Novel Marker of Oxidative Stress in Postmenopausal Osteoporosis |
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