Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy

We investigated the associations between methamphetamine (meth) use, immune function and the dynamics of HIV and cytomegalovirus [CMV] in the blood and genital tract of HIV-infected ART-suppressed subjects. Self-reported meth use was associated with increased CD4 + and CD8 + T-cell proliferation (Ki...

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Veröffentlicht in:	Scientific reports 2015-08, Vol.5 (1), p.13179-13179, Article 13179
Hauptverfasser:	Massanella, Marta, Gianella, Sara, Schrier, Rachel, Dan, Jennifer M., Pérez-Santiago, Josué, Oliveira, Michelli F., Richman, Douglas D., Little, Susan J., Benson, Constance A., Daar, Eric S., Dube, Michael P., Haubrich, Richard H., Smith, Davey M., Morris, Sheldon R.
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/2780 692/499 Adult Antiretroviral agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Blood Case-Control Studies Cell Proliferation Cytomegalovirus DNA, Viral - analysis HIV Antigens - immunology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Humanities and Social Sciences Humans Immune response Immune system Immunology Infections Lymphocytes Lymphocytes T Methamphetamine Methamphetamine - therapeutic use Middle Aged Monocytes - immunology multidisciplinary Pathogens Receptors, CCR5 - metabolism Science T cell receptors T-Lymphocytes - immunology Treatment Outcome
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Zusammenfassung:	We investigated the associations between methamphetamine (meth) use, immune function and the dynamics of HIV and cytomegalovirus [CMV] in the blood and genital tract of HIV-infected ART-suppressed subjects. Self-reported meth use was associated with increased CD4 + and CD8 + T-cell proliferation (Ki67 + , p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep13179