Olfactory identification deficits and increased mortality in the community
Objective To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults. Methods Participants were evaluated with the 40‐item University of Pennsylvania Smell Identification Test (UPSIT). Follow‐up occurred at 2‐year intervals...
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| Veröffentlicht in: | Annals of neurology 2015-09, Vol.78 (3), p.401-411 |
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| container_title | Annals of neurology |
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| creator | Devanand, Davangere P. Lee, Seonjoo Manly, Jennifer Andrews, Howard Schupf, Nicole Masurkar, Arjun Stern, Yaakov Mayeux, Richard Doty, Richard L. |
| description | Objective
To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults.
Methods
Participants were evaluated with the 40‐item University of Pennsylvania Smell Identification Test (UPSIT). Follow‐up occurred at 2‐year intervals with information on death obtained from informant interviews and the National Death Index.
Results
During follow‐up (mean = 4.1 years, standard deviation = 2.6), 349 of 1,169 (29.9%) participants died. Participants who died were more likely to be older (p |
| doi_str_mv | 10.1002/ana.24447 |
| format | Article |
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To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults.
Methods
Participants were evaluated with the 40‐item University of Pennsylvania Smell Identification Test (UPSIT). Follow‐up occurred at 2‐year intervals with information on death obtained from informant interviews and the National Death Index.
Results
During follow‐up (mean = 4.1 years, standard deviation = 2.6), 349 of 1,169 (29.9%) participants died. Participants who died were more likely to be older (p < 0.001), be male (p < 0.001), have lower UPSIT scores (p < 0.001), and have a diagnosis of dementia (p < 0.001). In a Cox model, the association between lower UPSIT score and mortality (hazard ratio [HR] = 1.07 per point interval, 95% confidence interval [CI] = 1.05–1.08, p < 0.001) persisted after controlling for age, gender, education, ethnicity, language, modified Charlson medical comorbidity index, dementia, depression, alcohol abuse, head injury, smoking, body mass index, and vision and hearing impairment (HR = 1.05, 95% CI = 1.03–1.07, p < 0.001). Compared to the fourth quartile with the highest UPSIT scores, HRs for mortality for the first, second, and third quartiles of UPSIT scores were 3.81 (95% CI = 2.71–5.34), 1.75 (95% CI = 1.23–2.50), and 1.58 (95% CI = 1.09–2.30), respectively. Participant mortality rate was 45% in the lowest quartile of UPSIT scores (anosmia) and 18% in the highest quartile of UPSIT scores.
Interpretation
Impaired odor identification, particularly in the anosmic range, is associated with increased mortality in older adults even after controlling for dementia and medical comorbidity. Ann Neurol 2015;78:401–411]]></description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.24447</identifier><identifier>PMID: 26031760</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aged ; Aged, 80 and over ; Cohort Studies ; Comorbidity ; Confidence intervals ; Dementia ; Female ; Follow-Up Studies ; Humans ; Male ; Mortality ; Mortality - trends ; Older people ; Olfaction Disorders - diagnosis ; Olfaction Disorders - mortality ; Residence Characteristics</subject><ispartof>Annals of neurology, 2015-09, Vol.78 (3), p.401-411</ispartof><rights>2015 American Neurological Association</rights><rights>2015 American Neurological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6507-9f168051155a138e08b04cc4db50aba0f7cfbdc655c505e4bbeff656ce51fccc3</citedby><cites>FETCH-LOGICAL-c6507-9f168051155a138e08b04cc4db50aba0f7cfbdc655c505e4bbeff656ce51fccc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.24447$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.24447$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26031760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devanand, Davangere P.</creatorcontrib><creatorcontrib>Lee, Seonjoo</creatorcontrib><creatorcontrib>Manly, Jennifer</creatorcontrib><creatorcontrib>Andrews, Howard</creatorcontrib><creatorcontrib>Schupf, Nicole</creatorcontrib><creatorcontrib>Masurkar, Arjun</creatorcontrib><creatorcontrib>Stern, Yaakov</creatorcontrib><creatorcontrib>Mayeux, Richard</creatorcontrib><creatorcontrib>Doty, Richard L.</creatorcontrib><title>Olfactory identification deficits and increased mortality in the community</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description><![CDATA[Objective
To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults.
Methods
Participants were evaluated with the 40‐item University of Pennsylvania Smell Identification Test (UPSIT). Follow‐up occurred at 2‐year intervals with information on death obtained from informant interviews and the National Death Index.
Results
During follow‐up (mean = 4.1 years, standard deviation = 2.6), 349 of 1,169 (29.9%) participants died. Participants who died were more likely to be older (p < 0.001), be male (p < 0.001), have lower UPSIT scores (p < 0.001), and have a diagnosis of dementia (p < 0.001). In a Cox model, the association between lower UPSIT score and mortality (hazard ratio [HR] = 1.07 per point interval, 95% confidence interval [CI] = 1.05–1.08, p < 0.001) persisted after controlling for age, gender, education, ethnicity, language, modified Charlson medical comorbidity index, dementia, depression, alcohol abuse, head injury, smoking, body mass index, and vision and hearing impairment (HR = 1.05, 95% CI = 1.03–1.07, p < 0.001). Compared to the fourth quartile with the highest UPSIT scores, HRs for mortality for the first, second, and third quartiles of UPSIT scores were 3.81 (95% CI = 2.71–5.34), 1.75 (95% CI = 1.23–2.50), and 1.58 (95% CI = 1.09–2.30), respectively. Participant mortality rate was 45% in the lowest quartile of UPSIT scores (anosmia) and 18% in the highest quartile of UPSIT scores.
Interpretation
Impaired odor identification, particularly in the anosmic range, is associated with increased mortality in older adults even after controlling for dementia and medical comorbidity. Ann Neurol 2015;78:401–411]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Dementia</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Mortality</subject><subject>Mortality - trends</subject><subject>Older people</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - mortality</subject><subject>Residence Characteristics</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhwB9AkbjAIe34O7kgrSq6FFXthS9xsRzHpi6J3dpJYf89brddlUpInDyyn3k0nhehlxj2MADZ10HvEcaYfIQWmFNcN4S1j9ECqGA1x5TtoGc5nwNAKzA8RTtEAMVSwAJ9PB2cNlNM68r3NkzeeaMnH0PV21L6KVc69JUPJlmdbV-NMU168FPhQzWd2crEcZxDuXiOnjg9ZPvi9txFnw_ffzr4UB-fro4Olse1ERxk3TosGuAYc64xbSw0HTBjWN9x0J0GJ43r-sJyw4Fb1nXWOcGFsRw7YwzdRe823ou5G21vytRJD-oi-VGntYraq79fgj9TP-KVYpwVDy6CN7eCFC9nmyc1-mzsMOhg45wVlphwQWRL_wMFQaBpiCzo6wfoeZxTKJu4prigLZeiUG83lEkx52Tddm4M6jpMVcJUN2EW9tX9j27Ju_QKsL8BfvnBrv9tUsuT5Z2y3nT4PNnf2w6dfiohqeTq68lKkbZdfcfii_pG_wBMbLjn</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Devanand, Davangere P.</creator><creator>Lee, Seonjoo</creator><creator>Manly, Jennifer</creator><creator>Andrews, Howard</creator><creator>Schupf, Nicole</creator><creator>Masurkar, Arjun</creator><creator>Stern, Yaakov</creator><creator>Mayeux, Richard</creator><creator>Doty, Richard L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201509</creationdate><title>Olfactory identification deficits and increased mortality in the community</title><author>Devanand, Davangere P. ; Lee, Seonjoo ; Manly, Jennifer ; Andrews, Howard ; Schupf, Nicole ; Masurkar, Arjun ; Stern, Yaakov ; Mayeux, Richard ; Doty, Richard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6507-9f168051155a138e08b04cc4db50aba0f7cfbdc655c505e4bbeff656ce51fccc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Dementia</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Mortality</topic><topic>Mortality - trends</topic><topic>Older people</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - mortality</topic><topic>Residence Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devanand, Davangere P.</creatorcontrib><creatorcontrib>Lee, Seonjoo</creatorcontrib><creatorcontrib>Manly, Jennifer</creatorcontrib><creatorcontrib>Andrews, Howard</creatorcontrib><creatorcontrib>Schupf, Nicole</creatorcontrib><creatorcontrib>Masurkar, Arjun</creatorcontrib><creatorcontrib>Stern, Yaakov</creatorcontrib><creatorcontrib>Mayeux, Richard</creatorcontrib><creatorcontrib>Doty, Richard L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devanand, Davangere P.</au><au>Lee, Seonjoo</au><au>Manly, Jennifer</au><au>Andrews, Howard</au><au>Schupf, Nicole</au><au>Masurkar, Arjun</au><au>Stern, Yaakov</au><au>Mayeux, Richard</au><au>Doty, Richard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olfactory identification deficits and increased mortality in the community</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>78</volume><issue>3</issue><spage>401</spage><epage>411</epage><pages>401-411</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract><![CDATA[Objective
To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults.
Methods
Participants were evaluated with the 40‐item University of Pennsylvania Smell Identification Test (UPSIT). Follow‐up occurred at 2‐year intervals with information on death obtained from informant interviews and the National Death Index.
Results
During follow‐up (mean = 4.1 years, standard deviation = 2.6), 349 of 1,169 (29.9%) participants died. Participants who died were more likely to be older (p < 0.001), be male (p < 0.001), have lower UPSIT scores (p < 0.001), and have a diagnosis of dementia (p < 0.001). In a Cox model, the association between lower UPSIT score and mortality (hazard ratio [HR] = 1.07 per point interval, 95% confidence interval [CI] = 1.05–1.08, p < 0.001) persisted after controlling for age, gender, education, ethnicity, language, modified Charlson medical comorbidity index, dementia, depression, alcohol abuse, head injury, smoking, body mass index, and vision and hearing impairment (HR = 1.05, 95% CI = 1.03–1.07, p < 0.001). Compared to the fourth quartile with the highest UPSIT scores, HRs for mortality for the first, second, and third quartiles of UPSIT scores were 3.81 (95% CI = 2.71–5.34), 1.75 (95% CI = 1.23–2.50), and 1.58 (95% CI = 1.09–2.30), respectively. Participant mortality rate was 45% in the lowest quartile of UPSIT scores (anosmia) and 18% in the highest quartile of UPSIT scores.
Interpretation
Impaired odor identification, particularly in the anosmic range, is associated with increased mortality in older adults even after controlling for dementia and medical comorbidity. Ann Neurol 2015;78:401–411]]></abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26031760</pmid><doi>10.1002/ana.24447</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 2015-09, Vol.78 (3), p.401-411 |
| issn | 0364-5134 1531-8249 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4546561 |
| source | MEDLINE; Wiley Journals |
| subjects | Aged Aged, 80 and over Cohort Studies Comorbidity Confidence intervals Dementia Female Follow-Up Studies Humans Male Mortality Mortality - trends Older people Olfaction Disorders - diagnosis Olfaction Disorders - mortality Residence Characteristics |
| title | Olfactory identification deficits and increased mortality in the community |
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