Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats
There is little information about the hepatoprotective effects of gallic acid against ischemia–reperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for t...
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| Veröffentlicht in: | Cytotechnology (Dordrecht) 2015-10, Vol.67 (5), p.845-849 |
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| creator | Bayramoglu, Gokhan Kurt, Hulyam Bayramoglu, Aysegul Gunes, Hasan Veysi Degirmenci, İrfan Colak, Suat |
| description | There is little information about the hepatoprotective effects of gallic acid against ischemia–reperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels. At the same time alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were assayed in serum samples and compared statistically. While the ALT, AST, LDH activities and MDA levels were significantly increased, CAT and GPx activities significantly decreased in only I/R-induced control rats compared to normal control rats (
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| doi_str_mv | 10.1007/s10616-014-9724-1 |
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P
< 0.05). Treatment with gallic acid at a dose of 100 mg/kg bw significantly decreased the ALT, AST, LDH activities and MDA levels, and markedly increased activities of CAT and GPx in tissue homogenates compared to I/R-induced rats with no treatment group (
P
< 0.05). In oxidative stress generated by hepatic ischemia–reperfusion, gallic acid contributes partially an alteration in the delicate balance between the scavenging capacity of antioxidant defense systems and free radicals in favour of the antioxidant defense systems in the body.</description><identifier>ISSN: 0920-9069</identifier><identifier>EISSN: 1573-0778</identifier><identifier>DOI: 10.1007/s10616-014-9724-1</identifier><identifier>PMID: 24811129</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acids ; Alanine transaminase ; Animals ; Antioxidants ; Aspartate aminotransferase ; Biochemistry ; Biomedicine ; Biotechnology ; Body weight ; Chemistry ; Chemistry and Materials Science ; Free radicals ; Gallic acid ; Glutathione peroxidase ; Ischemia ; L-Lactate dehydrogenase ; Lipid peroxidation ; Lipids ; Liver ; Original Research ; Oxidative stress ; Reperfusion ; Variance analysis</subject><ispartof>Cytotechnology (Dordrecht), 2015-10, Vol.67 (5), p.845-849</ispartof><rights>Springer Science+Business Media Dordrecht 2014</rights><rights>Springer Science+Business Media Dordrecht 2014.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-2141fb1a78cc14fab0934b475de8c40991a024e8111a37f0e59e0ed3d73988243</citedby><cites>FETCH-LOGICAL-c503t-2141fb1a78cc14fab0934b475de8c40991a024e8111a37f0e59e0ed3d73988243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545446/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918264957?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21388,27924,27925,33744,33745,41488,42557,43805,51319,53791,53793,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24811129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bayramoglu, Gokhan</creatorcontrib><creatorcontrib>Kurt, Hulyam</creatorcontrib><creatorcontrib>Bayramoglu, Aysegul</creatorcontrib><creatorcontrib>Gunes, Hasan Veysi</creatorcontrib><creatorcontrib>Degirmenci, İrfan</creatorcontrib><creatorcontrib>Colak, Suat</creatorcontrib><title>Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats</title><title>Cytotechnology (Dordrecht)</title><addtitle>Cytotechnology</addtitle><addtitle>Cytotechnology</addtitle><description>There is little information about the hepatoprotective effects of gallic acid against ischemia–reperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels. At the same time alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were assayed in serum samples and compared statistically. While the ALT, AST, LDH activities and MDA levels were significantly increased, CAT and GPx activities significantly decreased in only I/R-induced control rats compared to normal control rats (
P
< 0.05). Treatment with gallic acid at a dose of 100 mg/kg bw significantly decreased the ALT, AST, LDH activities and MDA levels, and markedly increased activities of CAT and GPx in tissue homogenates compared to I/R-induced rats with no treatment group (
P
< 0.05). In oxidative stress generated by hepatic ischemia–reperfusion, gallic acid contributes partially an alteration in the delicate balance between the scavenging capacity of antioxidant defense systems and free radicals in favour of the antioxidant defense systems in the body.</description><subject>Acids</subject><subject>Alanine transaminase</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Aspartate aminotransferase</subject><subject>Biochemistry</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Body weight</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Free radicals</subject><subject>Gallic acid</subject><subject>Glutathione peroxidase</subject><subject>Ischemia</subject><subject>L-Lactate dehydrogenase</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Original Research</subject><subject>Oxidative stress</subject><subject>Reperfusion</subject><subject>Variance analysis</subject><issn>0920-9069</issn><issn>1573-0778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UcFq3DAQFSWh2Wz7AbkEQS69uJ2RZcu6FEJo00KgCaRnoZXHu1q81layF_L31XbTJA2UOQzDvHkzbx5jZwgfEUB9Sgg11gWgLLQSssA3bIaVKgtQqjliM9ACCg21PmGnKa0BQCss37ITIRtEFHrG7m4j7WgY_Y54DD3x0PGl7XvvuHW-5WHgK9raMdc-uRVtvOV2aHmkLcVuSj4D_LCe4kNOPNoxvWPHne0TvX_Mc_bz65f7q2_FzY_r71eXN4WroBwLgRK7BVrVOIeyswvQpVxIVbXUOAlaowUhaX-nLVUHVGkCastWlbpphCzn7POBdzstNtS6LCLa3myj39j4YIL15t_O4FdmGXZGVjlknQk-PBLE8GuiNJpNlkh9bwcKUzKooBagqz-7Ll5B12GKQ5ZnhMZG1FLnt88ZHlAuhpQidU_HIJi9YeZgmMmGmb1hBvPM-UsVTxN_HcoAcQCk3BqWFJ9X_5_1N4EfoIw</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Bayramoglu, Gokhan</creator><creator>Kurt, Hulyam</creator><creator>Bayramoglu, Aysegul</creator><creator>Gunes, Hasan Veysi</creator><creator>Degirmenci, İrfan</creator><creator>Colak, Suat</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151001</creationdate><title>Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats</title><author>Bayramoglu, Gokhan ; Kurt, Hulyam ; Bayramoglu, Aysegul ; Gunes, Hasan Veysi ; Degirmenci, İrfan ; Colak, Suat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-2141fb1a78cc14fab0934b475de8c40991a024e8111a37f0e59e0ed3d73988243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Alanine transaminase</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Aspartate aminotransferase</topic><topic>Biochemistry</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Body weight</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Free radicals</topic><topic>Gallic acid</topic><topic>Glutathione peroxidase</topic><topic>Ischemia</topic><topic>L-Lactate dehydrogenase</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver</topic><topic>Original Research</topic><topic>Oxidative stress</topic><topic>Reperfusion</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bayramoglu, Gokhan</creatorcontrib><creatorcontrib>Kurt, Hulyam</creatorcontrib><creatorcontrib>Bayramoglu, Aysegul</creatorcontrib><creatorcontrib>Gunes, Hasan Veysi</creatorcontrib><creatorcontrib>Degirmenci, İrfan</creatorcontrib><creatorcontrib>Colak, Suat</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cytotechnology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bayramoglu, Gokhan</au><au>Kurt, Hulyam</au><au>Bayramoglu, Aysegul</au><au>Gunes, Hasan Veysi</au><au>Degirmenci, İrfan</au><au>Colak, Suat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats</atitle><jtitle>Cytotechnology (Dordrecht)</jtitle><stitle>Cytotechnology</stitle><addtitle>Cytotechnology</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>67</volume><issue>5</issue><spage>845</spage><epage>849</epage><pages>845-849</pages><issn>0920-9069</issn><eissn>1573-0778</eissn><abstract>There is little information about the hepatoprotective effects of gallic acid against ischemia–reperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels. At the same time alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were assayed in serum samples and compared statistically. While the ALT, AST, LDH activities and MDA levels were significantly increased, CAT and GPx activities significantly decreased in only I/R-induced control rats compared to normal control rats (
P
< 0.05). Treatment with gallic acid at a dose of 100 mg/kg bw significantly decreased the ALT, AST, LDH activities and MDA levels, and markedly increased activities of CAT and GPx in tissue homogenates compared to I/R-induced rats with no treatment group (
P
< 0.05). In oxidative stress generated by hepatic ischemia–reperfusion, gallic acid contributes partially an alteration in the delicate balance between the scavenging capacity of antioxidant defense systems and free radicals in favour of the antioxidant defense systems in the body.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24811129</pmid><doi>10.1007/s10616-014-9724-1</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; PubMed Central; ProQuest Central |
| subjects | Acids Alanine transaminase Animals Antioxidants Aspartate aminotransferase Biochemistry Biomedicine Biotechnology Body weight Chemistry Chemistry and Materials Science Free radicals Gallic acid Glutathione peroxidase Ischemia L-Lactate dehydrogenase Lipid peroxidation Lipids Liver Original Research Oxidative stress Reperfusion Variance analysis |
| title | Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats |
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