Validating the GTP‐cyclohydrolase 1‐feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

Background and Purpose 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients. Unfortunately, oral BH4 has limited efficacy. Therefore, orally bioavaila...

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Veröffentlicht in:	British journal of pharmacology 2015-08, Vol.172 (16), p.4146-4157
Hauptverfasser:	Hussein, D, Starr, A, Heikal, L, McNeill, E, Channon, K M, Brown, P R, Sutton, B J, McDonnell, J M, Nandi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopterins - analogs & derivatives Biopterins - blood Biopterins - metabolism Cell Line GTP Cyclohydrolase - genetics GTP Cyclohydrolase - metabolism Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male Mice, Inbred C57BL Mice, Transgenic Nitric Oxide - metabolism Phenylalanine - pharmacology Research Papers RNA, Messenger - metabolism Superoxides - metabolism
Online-Zugang:	Volltext
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