SMN deficiency disrupts gastrointestinal and enteric nervous system function in mice

The 2007 Consensus Statement for Standard of Care in Spinal Muscular Atrophy (SMA) notes that patients suffer from gastroesophageal reflux, constipation and delayed gastric emptying. We used two mouse models of SMA to determine whether functional GI complications are a direct consequence of or are s...

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Veröffentlicht in:	Human molecular genetics 2015-07, Vol.24 (13), p.3847-3860
Hauptverfasser:	Gombash, Sara E, Cowley, Christopher J, Fitzgerald, Julie A, Iyer, Chitra C, Fried, David, McGovern, Vicki L, Williams, Kent C, Burghes, Arthur H M, Christofi, Fedias L, Gulbransen, Brian D, Foust, Kevin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Enteric Nervous System - physiopathology Female Gastric Emptying Gastrointestinal Diseases - etiology Gastrointestinal Diseases - genetics Gastrointestinal Diseases - metabolism Gastrointestinal Diseases - physiopathology Gastrointestinal Tract - innervation Gastrointestinal Tract - physiopathology Humans Male Mice Muscular Atrophy, Spinal - complications Muscular Atrophy, Spinal - genetics Muscular Atrophy, Spinal - metabolism Survival of Motor Neuron 1 Protein - genetics Survival of Motor Neuron 1 Protein - metabolism Survival of Motor Neuron 2 Protein - chemistry Survival of Motor Neuron 2 Protein - deficiency Survival of Motor Neuron 2 Protein - genetics
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