Human cell dedifferentiation in mesenchymal condensates through controlled autophagy

Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacement tissues develop. Human somatic cells cannot re...

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Veröffentlicht in:	Scientific reports 2015-08, Vol.5 (1), p.13113-13113, Article 13113
Hauptverfasser:	Pennock, Rebecca, Bray, Elen, Pryor, Paul, James, Sally, McKeegan, Paul, Sturmey, Roger, Genever, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/80 Age Aged Autophagy Cartilage Cell Culture Techniques Cell Dedifferentiation Condensates Cytoplasm - metabolism Endoderm - cytology Humanities and Social Sciences Humans Hypertrophy Mammals Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Mesendoderm Metabolism Middle Aged Mitochondria multidisciplinary Oxidative metabolism Oxidative phosphorylation Phagocytosis Phosphorylation Physiology Population Regeneration Science Somatic cells Stem cells Stromal cells Tissue engineering
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