Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection
During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been define...
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| Veröffentlicht in: | BMC infectious diseases 2015-08, Vol.15 (1), p.342-342, Article 342 |
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| container_title | BMC infectious diseases |
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| creator | Diao, Yingying Geng, Wenqing Fan, Xuejie Cui, Hualu Sun, Hong Jiang, Yongjun Wang, Yanan Sun, Amy Shang, Hong |
| description | During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been defined.
EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion were assessed by flow cytometry in 29 patients.
When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers. CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads. IL-12 secretion was only positively associated with CD4+ T cell counts. Rapid progressors had lower counts, CD86 expression, and IL-12 secretion of CD1c + mDCs comparing with typical progressors. Kaplan-Meier analysis and Cox regression models suggested patients with low CD1c + mDC counts ( |
| doi_str_mv | 10.1186/s12879-015-1092-8 |
| format | Article |
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EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion were assessed by flow cytometry in 29 patients.
When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers. CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads. IL-12 secretion was only positively associated with CD4+ T cell counts. Rapid progressors had lower counts, CD86 expression, and IL-12 secretion of CD1c + mDCs comparing with typical progressors. Kaplan-Meier analysis and Cox regression models suggested patients with low CD1c + mDC counts (<10 cells/μL) had a 4-fold higher risk of rapid disease progression than those with high CD1c + mDC counts. However, no relationship was found between surface markers or IL-12 secretion and disease progression.
During EHI, patients with low CD1c + mDC counts were more likely to experience rapid disease progression than those with high CD1c + mDC counts.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/s12879-015-1092-8</identifier><identifier>PMID: 26286082</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Antigens, CD1 - immunology ; CD4-Positive T-Lymphocytes - immunology ; China ; Cohort Studies ; Comparative analysis ; Dendritic Cells - immunology ; Disease Progression ; Flow Cytometry ; Glycoproteins - immunology ; Health aspects ; HIV Infections - immunology ; HIV Infections - mortality ; HIV-1 - immunology ; Homosexuality, Male ; Humans ; Immune response ; Interleukin-12 - metabolism ; Kaplan-Meier Estimate ; Male ; Medical research ; Medicine, Experimental ; Myeloid Cells - immunology ; Young Adult</subject><ispartof>BMC infectious diseases, 2015-08, Vol.15 (1), p.342-342, Article 342</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Diao et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-5fc1f5902dfb04a98bcaf1581b3debac89c27545e89bd400084f7fe2884bd3ed3</citedby><cites>FETCH-LOGICAL-c534t-5fc1f5902dfb04a98bcaf1581b3debac89c27545e89bd400084f7fe2884bd3ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541738/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541738/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26286082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diao, Yingying</creatorcontrib><creatorcontrib>Geng, Wenqing</creatorcontrib><creatorcontrib>Fan, Xuejie</creatorcontrib><creatorcontrib>Cui, Hualu</creatorcontrib><creatorcontrib>Sun, Hong</creatorcontrib><creatorcontrib>Jiang, Yongjun</creatorcontrib><creatorcontrib>Wang, Yanan</creatorcontrib><creatorcontrib>Sun, Amy</creatorcontrib><creatorcontrib>Shang, Hong</creatorcontrib><title>Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been defined.
EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion were assessed by flow cytometry in 29 patients.
When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers. CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads. IL-12 secretion was only positively associated with CD4+ T cell counts. Rapid progressors had lower counts, CD86 expression, and IL-12 secretion of CD1c + mDCs comparing with typical progressors. Kaplan-Meier analysis and Cox regression models suggested patients with low CD1c + mDC counts (<10 cells/μL) had a 4-fold higher risk of rapid disease progression than those with high CD1c + mDC counts. However, no relationship was found between surface markers or IL-12 secretion and disease progression.
During EHI, patients with low CD1c + mDC counts were more likely to experience rapid disease progression than those with high CD1c + mDC counts.</description><subject>Adult</subject><subject>Antigens, CD1 - immunology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>China</subject><subject>Cohort Studies</subject><subject>Comparative analysis</subject><subject>Dendritic Cells - immunology</subject><subject>Disease Progression</subject><subject>Flow Cytometry</subject><subject>Glycoproteins - immunology</subject><subject>Health aspects</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - mortality</subject><subject>HIV-1 - immunology</subject><subject>Homosexuality, Male</subject><subject>Humans</subject><subject>Immune response</subject><subject>Interleukin-12 - metabolism</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Myeloid Cells - immunology</subject><subject>Young Adult</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktr3DAUhU1paR7tD-imCLppKE71HMubQpg-MjAQ6CNbIUtXHrW2NZHsprPpb6_MpCEDXRQtrtD9zgEdTlG8IPicELl4mwiVVV1iIkqCa1rKR8Ux4RUpKWP88YP7UXGS0neMSSVp_bQ4ogsqF1jS4-L3Otyi5Xti0BvU76AL3iILg41-9AYZ6DpkwjSMKY8YodMjWHTrxw3SaOPbDYo-_UDBoai3s9Qn0AnQNoY2Qko-DMhO0Q8tAh27HbpcXZcE-cGBGfPyWfHE6S7B87t5Wnz7-OHr8rJcX31aLS_WpRGMj6VwhjhRY2pdg7muZWO0I0KShllotJG1oZXgAmTdWI4xltxVDqiUvLEMLDst3u19t1PTgzUwjFF3aht9r-NOBe3V4WbwG9WGn4oLTioms8HrO4MYbiZIo-p9muPRA4QpKVJhUTGGSZ3RV3u01R2o_NWQHc2Mq4vsxmosFixT5_-g8rHQexMGcD6_HwjODgSZGeHX2OopJbX68vn_2avrQ5bsWRNDShHcfSoEq7lmal8zlWum5pqpOY2XD-O8V_ztFfsDSAXMtg</recordid><startdate>20150819</startdate><enddate>20150819</enddate><creator>Diao, Yingying</creator><creator>Geng, Wenqing</creator><creator>Fan, Xuejie</creator><creator>Cui, Hualu</creator><creator>Sun, Hong</creator><creator>Jiang, Yongjun</creator><creator>Wang, Yanan</creator><creator>Sun, Amy</creator><creator>Shang, Hong</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150819</creationdate><title>Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection</title><author>Diao, Yingying ; Geng, Wenqing ; Fan, Xuejie ; Cui, Hualu ; Sun, Hong ; Jiang, Yongjun ; Wang, Yanan ; Sun, Amy ; Shang, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-5fc1f5902dfb04a98bcaf1581b3debac89c27545e89bd400084f7fe2884bd3ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Antigens, CD1 - immunology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>China</topic><topic>Cohort Studies</topic><topic>Comparative analysis</topic><topic>Dendritic Cells - immunology</topic><topic>Disease Progression</topic><topic>Flow Cytometry</topic><topic>Glycoproteins - immunology</topic><topic>Health aspects</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - mortality</topic><topic>HIV-1 - immunology</topic><topic>Homosexuality, Male</topic><topic>Humans</topic><topic>Immune response</topic><topic>Interleukin-12 - metabolism</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Myeloid Cells - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diao, Yingying</creatorcontrib><creatorcontrib>Geng, Wenqing</creatorcontrib><creatorcontrib>Fan, Xuejie</creatorcontrib><creatorcontrib>Cui, Hualu</creatorcontrib><creatorcontrib>Sun, Hong</creatorcontrib><creatorcontrib>Jiang, Yongjun</creatorcontrib><creatorcontrib>Wang, Yanan</creatorcontrib><creatorcontrib>Sun, Amy</creatorcontrib><creatorcontrib>Shang, Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diao, Yingying</au><au>Geng, Wenqing</au><au>Fan, Xuejie</au><au>Cui, Hualu</au><au>Sun, Hong</au><au>Jiang, Yongjun</au><au>Wang, Yanan</au><au>Sun, Amy</au><au>Shang, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection</atitle><jtitle>BMC infectious diseases</jtitle><addtitle>BMC Infect Dis</addtitle><date>2015-08-19</date><risdate>2015</risdate><volume>15</volume><issue>1</issue><spage>342</spage><epage>342</epage><pages>342-342</pages><artnum>342</artnum><issn>1471-2334</issn><eissn>1471-2334</eissn><abstract>During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been defined.
EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion were assessed by flow cytometry in 29 patients.
When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers. CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads. IL-12 secretion was only positively associated with CD4+ T cell counts. Rapid progressors had lower counts, CD86 expression, and IL-12 secretion of CD1c + mDCs comparing with typical progressors. Kaplan-Meier analysis and Cox regression models suggested patients with low CD1c + mDC counts (<10 cells/μL) had a 4-fold higher risk of rapid disease progression than those with high CD1c + mDC counts. However, no relationship was found between surface markers or IL-12 secretion and disease progression.
During EHI, patients with low CD1c + mDC counts were more likely to experience rapid disease progression than those with high CD1c + mDC counts.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26286082</pmid><doi>10.1186/s12879-015-1092-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerNature Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Antigens, CD1 - immunology CD4-Positive T-Lymphocytes - immunology China Cohort Studies Comparative analysis Dendritic Cells - immunology Disease Progression Flow Cytometry Glycoproteins - immunology Health aspects HIV Infections - immunology HIV Infections - mortality HIV-1 - immunology Homosexuality, Male Humans Immune response Interleukin-12 - metabolism Kaplan-Meier Estimate Male Medical research Medicine, Experimental Myeloid Cells - immunology Young Adult |
| title | Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection |
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