Ganglion cell complex thickness in nonexudative age-related macular degeneration
Purpose To evaluate ganglion cell complex (GCC) thickness with spectral domain optical coherence tomography (SD-OCT) in eyes with nonexudative age-related macular degeneration (NEAMD). Methods Forty-seven eyes of 28 patients with nonexudative age-related macular degeneration (NEAMD) and 54 eyes of 2...
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| Veröffentlicht in: | Eye (London) 2015-08, Vol.29 (8), p.1076-1080 |
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| creator | Yenice, E Şengün, A Soyugelen Demirok, G Turaçlı, E |
| description | Purpose
To evaluate ganglion cell complex (GCC) thickness with spectral domain optical coherence tomography (SD-OCT) in eyes with nonexudative age-related macular degeneration (NEAMD).
Methods
Forty-seven eyes of 28 patients with nonexudative age-related macular degeneration (NEAMD) and 54 eyes of 28 age-matched healthy subjects were enrolled. Each subject underwent a complete ophthalmic examination before SD-OCT were obtained. Macular scans were taken with software version 6.0 of the ganglion cell analysis (GCA) algorithm. GCC thickness was evaluated automatically as the average, minimum, temporal superior, superior, nasal superior, nasal inferior, inferior, and temporal-inferior segments by SD-OCT and parameters were compared between groups.
Results
The mean age was 68.7±8.73 years in patient group, and 61.51±5.66 years in control group. There were no significant differences in mean age, gender distribution, intraocular pressure, and sferic equivalent at imaging between the groups (
P
>0.05). The mean (±SD) GCC thicknesses were as follows; average 71.53±16.53
μ
m, minumum 62.36±21.51
μ
m, temporal superior 72.23±14.60
μ
m, superior 72.76±20.40
μ
m, nasal superior 72.31±20.13
μ
m, nasal inferior 69.74±20.51
μ
m, inferior 69.38±19.03
μ
m, and temporal-inferior 73.12±15.44
μ
m in patient group. Corresponding values in control group were 81.46±4.90
μ
m, 78.66±6.00
μ
m, 81.51±4.66
μ
m, 82.94±5.14
μ
m, 81.79±5.86
μ
m, 80.94±6.18
μ
m, 80.14±6.30
μ
m, and 81.75±5.26
μ
m, respectively. There were significant differences between two groups in each segments (Mann–Whitney
U
-test,
P |
| doi_str_mv | 10.1038/eye.2015.86 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4541357</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3776121261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-684249c4423c0c4321666d9505a2237db59757fe183375f13df51216939e67f23</originalsourceid><addsrcrecordid>eNqNkc1P3DAQxS1U1N0uPXGvIvVSqWTxt5MLUoVaQEJqD1TqzTLOJBtI7MVOVst_j6MFBBUHLvbh_fRm5j2EDgleEsyKY7iHJcVELAu5h-aEK5kLLvgHNMelwDml9N8MfYrxBuMkKvwRzajElBSymKM_Z8Y1XetdZqHrMuv7dQfbbFi19tZBjFnrMucdbMfKDO0GMtNAHqAzA1RZb-zYmZBV0ICDkADvDtB-bboInx__Bfr76-fV6Xl--fvs4vTHZW65KodcFpzy0nJOmcWWM0qklFXaVxhKmaquRamEqoEUjClRE1bVgiSoZCVIVVO2QCc73_V43UNlwQ3BdHod2t6Ee-1Nq18rrl3pxm90ioYwoZLBt0eD4O9GiIPu2ziFYBz4MWqiBOOKSyHegWLOeDEds0Bf_0Nv_BhcSmKi0tz0Tobfd5QNPsYA9fPeBOupVJ1K1VOpupCJ_vLy1Gf2qcUEHO2AmCTXQHgx9A2_B9Kuqt8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1703571705</pqid></control><display><type>article</type><title>Ganglion cell complex thickness in nonexudative age-related macular degeneration</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yenice, E ; Şengün, A ; Soyugelen Demirok, G ; Turaçlı, E</creator><creatorcontrib>Yenice, E ; Şengün, A ; Soyugelen Demirok, G ; Turaçlı, E</creatorcontrib><description>Purpose
To evaluate ganglion cell complex (GCC) thickness with spectral domain optical coherence tomography (SD-OCT) in eyes with nonexudative age-related macular degeneration (NEAMD).
Methods
Forty-seven eyes of 28 patients with nonexudative age-related macular degeneration (NEAMD) and 54 eyes of 28 age-matched healthy subjects were enrolled. Each subject underwent a complete ophthalmic examination before SD-OCT were obtained. Macular scans were taken with software version 6.0 of the ganglion cell analysis (GCA) algorithm. GCC thickness was evaluated automatically as the average, minimum, temporal superior, superior, nasal superior, nasal inferior, inferior, and temporal-inferior segments by SD-OCT and parameters were compared between groups.
Results
The mean age was 68.7±8.73 years in patient group, and 61.51±5.66 years in control group. There were no significant differences in mean age, gender distribution, intraocular pressure, and sferic equivalent at imaging between the groups (
P
>0.05). The mean (±SD) GCC thicknesses were as follows; average 71.53±16.53
μ
m, minumum 62.36±21.51
μ
m, temporal superior 72.23±14.60
μ
m, superior 72.76±20.40
μ
m, nasal superior 72.31±20.13
μ
m, nasal inferior 69.74±20.51
μ
m, inferior 69.38±19.03
μ
m, and temporal-inferior 73.12±15.44
μ
m in patient group. Corresponding values in control group were 81.46±4.90
μ
m, 78.66±6.00
μ
m, 81.51±4.66
μ
m, 82.94±5.14
μ
m, 81.79±5.86
μ
m, 80.94±6.18
μ
m, 80.14±6.30
μ
m, and 81.75±5.26
μ
m, respectively. There were significant differences between two groups in each segments (Mann–Whitney
U
-test,
P
<0.05).
Conclusion
The average GCC thickness values (in all segments) of NEAMD patients were lower than control group. NEAMD, which is considered as a disease of outer layers of retina, may be accompanied with a decrease of ganglion cell thickness, so inner layers of retina may be affected.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2015.86</identifier><identifier>PMID: 26021868</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14 ; 14/105 ; 692/699/3161/3175 ; Aged ; Case-Control Studies ; Clinical Study ; Female ; Geographic Atrophy ; Humans ; Intraocular Pressure ; Laboratory Medicine ; Macular Degeneration - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nerve Fibers - pathology ; Ophthalmology ; Optic Disk ; Pharmaceutical Sciences/Technology ; Retinal Ganglion Cells - pathology ; Retrospective Studies ; Surgery ; Surgical Oncology ; Tomography, Optical Coherence - methods ; Visual Acuity</subject><ispartof>Eye (London), 2015-08, Vol.29 (8), p.1076-1080</ispartof><rights>Royal College of Ophthalmologists 2015</rights><rights>Copyright Nature Publishing Group Aug 2015</rights><rights>Copyright © 2015 Royal College of Ophthalmologists 2015 Royal College of Ophthalmologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-684249c4423c0c4321666d9505a2237db59757fe183375f13df51216939e67f23</citedby><cites>FETCH-LOGICAL-c479t-684249c4423c0c4321666d9505a2237db59757fe183375f13df51216939e67f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541357/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541357/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26021868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yenice, E</creatorcontrib><creatorcontrib>Şengün, A</creatorcontrib><creatorcontrib>Soyugelen Demirok, G</creatorcontrib><creatorcontrib>Turaçlı, E</creatorcontrib><title>Ganglion cell complex thickness in nonexudative age-related macular degeneration</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To evaluate ganglion cell complex (GCC) thickness with spectral domain optical coherence tomography (SD-OCT) in eyes with nonexudative age-related macular degeneration (NEAMD).
Methods
Forty-seven eyes of 28 patients with nonexudative age-related macular degeneration (NEAMD) and 54 eyes of 28 age-matched healthy subjects were enrolled. Each subject underwent a complete ophthalmic examination before SD-OCT were obtained. Macular scans were taken with software version 6.0 of the ganglion cell analysis (GCA) algorithm. GCC thickness was evaluated automatically as the average, minimum, temporal superior, superior, nasal superior, nasal inferior, inferior, and temporal-inferior segments by SD-OCT and parameters were compared between groups.
Results
The mean age was 68.7±8.73 years in patient group, and 61.51±5.66 years in control group. There were no significant differences in mean age, gender distribution, intraocular pressure, and sferic equivalent at imaging between the groups (
P
>0.05). The mean (±SD) GCC thicknesses were as follows; average 71.53±16.53
μ
m, minumum 62.36±21.51
μ
m, temporal superior 72.23±14.60
μ
m, superior 72.76±20.40
μ
m, nasal superior 72.31±20.13
μ
m, nasal inferior 69.74±20.51
μ
m, inferior 69.38±19.03
μ
m, and temporal-inferior 73.12±15.44
μ
m in patient group. Corresponding values in control group were 81.46±4.90
μ
m, 78.66±6.00
μ
m, 81.51±4.66
μ
m, 82.94±5.14
μ
m, 81.79±5.86
μ
m, 80.94±6.18
μ
m, 80.14±6.30
μ
m, and 81.75±5.26
μ
m, respectively. There were significant differences between two groups in each segments (Mann–Whitney
U
-test,
P
<0.05).
Conclusion
The average GCC thickness values (in all segments) of NEAMD patients were lower than control group. NEAMD, which is considered as a disease of outer layers of retina, may be accompanied with a decrease of ganglion cell thickness, so inner layers of retina may be affected.</description><subject>14</subject><subject>14/105</subject><subject>692/699/3161/3175</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Clinical Study</subject><subject>Female</subject><subject>Geographic Atrophy</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Laboratory Medicine</subject><subject>Macular Degeneration - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>Optic Disk</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Visual Acuity</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1P3DAQxS1U1N0uPXGvIvVSqWTxt5MLUoVaQEJqD1TqzTLOJBtI7MVOVst_j6MFBBUHLvbh_fRm5j2EDgleEsyKY7iHJcVELAu5h-aEK5kLLvgHNMelwDml9N8MfYrxBuMkKvwRzajElBSymKM_Z8Y1XetdZqHrMuv7dQfbbFi19tZBjFnrMucdbMfKDO0GMtNAHqAzA1RZb-zYmZBV0ICDkADvDtB-bboInx__Bfr76-fV6Xl--fvs4vTHZW65KodcFpzy0nJOmcWWM0qklFXaVxhKmaquRamEqoEUjClRE1bVgiSoZCVIVVO2QCc73_V43UNlwQ3BdHod2t6Ee-1Nq18rrl3pxm90ioYwoZLBt0eD4O9GiIPu2ziFYBz4MWqiBOOKSyHegWLOeDEds0Bf_0Nv_BhcSmKi0tz0Tobfd5QNPsYA9fPeBOupVJ1K1VOpupCJ_vLy1Gf2qcUEHO2AmCTXQHgx9A2_B9Kuqt8</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Yenice, E</creator><creator>Şengün, A</creator><creator>Soyugelen Demirok, G</creator><creator>Turaçlı, E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150801</creationdate><title>Ganglion cell complex thickness in nonexudative age-related macular degeneration</title><author>Yenice, E ; Şengün, A ; Soyugelen Demirok, G ; Turaçlı, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-684249c4423c0c4321666d9505a2237db59757fe183375f13df51216939e67f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>14</topic><topic>14/105</topic><topic>692/699/3161/3175</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Clinical Study</topic><topic>Female</topic><topic>Geographic Atrophy</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Laboratory Medicine</topic><topic>Macular Degeneration - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>Optic Disk</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yenice, E</creatorcontrib><creatorcontrib>Şengün, A</creatorcontrib><creatorcontrib>Soyugelen Demirok, G</creatorcontrib><creatorcontrib>Turaçlı, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yenice, E</au><au>Şengün, A</au><au>Soyugelen Demirok, G</au><au>Turaçlı, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ganglion cell complex thickness in nonexudative age-related macular degeneration</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>29</volume><issue>8</issue><spage>1076</spage><epage>1080</epage><pages>1076-1080</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Purpose
To evaluate ganglion cell complex (GCC) thickness with spectral domain optical coherence tomography (SD-OCT) in eyes with nonexudative age-related macular degeneration (NEAMD).
Methods
Forty-seven eyes of 28 patients with nonexudative age-related macular degeneration (NEAMD) and 54 eyes of 28 age-matched healthy subjects were enrolled. Each subject underwent a complete ophthalmic examination before SD-OCT were obtained. Macular scans were taken with software version 6.0 of the ganglion cell analysis (GCA) algorithm. GCC thickness was evaluated automatically as the average, minimum, temporal superior, superior, nasal superior, nasal inferior, inferior, and temporal-inferior segments by SD-OCT and parameters were compared between groups.
Results
The mean age was 68.7±8.73 years in patient group, and 61.51±5.66 years in control group. There were no significant differences in mean age, gender distribution, intraocular pressure, and sferic equivalent at imaging between the groups (
P
>0.05). The mean (±SD) GCC thicknesses were as follows; average 71.53±16.53
μ
m, minumum 62.36±21.51
μ
m, temporal superior 72.23±14.60
μ
m, superior 72.76±20.40
μ
m, nasal superior 72.31±20.13
μ
m, nasal inferior 69.74±20.51
μ
m, inferior 69.38±19.03
μ
m, and temporal-inferior 73.12±15.44
μ
m in patient group. Corresponding values in control group were 81.46±4.90
μ
m, 78.66±6.00
μ
m, 81.51±4.66
μ
m, 82.94±5.14
μ
m, 81.79±5.86
μ
m, 80.94±6.18
μ
m, 80.14±6.30
μ
m, and 81.75±5.26
μ
m, respectively. There were significant differences between two groups in each segments (Mann–Whitney
U
-test,
P
<0.05).
Conclusion
The average GCC thickness values (in all segments) of NEAMD patients were lower than control group. NEAMD, which is considered as a disease of outer layers of retina, may be accompanied with a decrease of ganglion cell thickness, so inner layers of retina may be affected.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26021868</pmid><doi>10.1038/eye.2015.86</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-222X |
| ispartof | Eye (London), 2015-08, Vol.29 (8), p.1076-1080 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4541357 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | 14 14/105 692/699/3161/3175 Aged Case-Control Studies Clinical Study Female Geographic Atrophy Humans Intraocular Pressure Laboratory Medicine Macular Degeneration - pathology Male Medicine Medicine & Public Health Middle Aged Nerve Fibers - pathology Ophthalmology Optic Disk Pharmaceutical Sciences/Technology Retinal Ganglion Cells - pathology Retrospective Studies Surgery Surgical Oncology Tomography, Optical Coherence - methods Visual Acuity |
| title | Ganglion cell complex thickness in nonexudative age-related macular degeneration |
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