5,10-Methylenetetrahydrofolate Reductase 677 and 1298 Polymorphisms, Folate Intake, and Microsatellite Instability in Colon Cancer

The 5,10-methylenetetrahydrofolate reductase ( MTHFR ) gene plays a critical role in folate metabolism. Studies on the association between MTHFR polymorphisms and length changes in short tandem repeat DNA sequences [microsatellite instability (MSI)] are inconsistent. Using data from colon cancer cas...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-08, Vol.14 (8), p.2023-2029
Hauptverfasser:	EATON, Allison M, SANDLER, Robert, CARETHERS, John M, MILLIKAN, Robert C, GALANKO, Joseph, KEKU, Temitope O
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Case-Control Studies Colonic Neoplasms - genetics DNA methylation Female folate Folic Acid - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Genotype Hematinics - administration & dosage human colon cancer Humans Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) - genetics microsatellite instability Microsatellite Repeats Middle Aged MTHFR polymorphisms Polymorphism, Genetic Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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