Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma

Lactoferrin (Lf) is a potential-targeting ligand for hepatocellular carcinoma (HCC) cells because of its specific binding with asialoglycoprotein receptor (ASGPR). In this present work, a doxorubicin (DOX)-loaded, Lf-modified, polyethylene glycol (PEG)ylated liposome (Lf-PLS) system was developed, a...

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Veröffentlicht in:	International journal of nanomedicine 2015-01, Vol.10, p.5123-5137
Hauptverfasser:	Wei, Minyan, Guo, Xiucai, Tu, Liuxiao, Zou, Qi, Li, Qi, Tang, Chenyi, Chen, Bao, Xu, Yuehong, Wu, Chuanbin
Format:	Artikel
Sprache:	eng
Schlagworte:	active targeting Animals Antineoplastic Agents - chemistry Asialoglycoprotein Receptor Biomedical materials Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Care and treatment Cell Line Cell Proliferation Chromatography Cytotoxicity Dosage and administration Doxorubicin Doxorubicin - analogs & derivatives Doxorubicin - chemistry Drug delivery systems Drugs Flow Cytometry Hep G2 Cells hepatic cancer Hepatoma Humans immunoliposome Innovations Laboratory animals Lactoferrin - chemistry Ligands Lipids Liposomes Liposomes - chemistry Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Nanoparticles NIH 3T3 Cells Original Research Particle Size PEGylated modification Pharmaceutical sciences Polyethylene glycol Polyethylene Glycols - chemistry post-insertion Thin films Vehicles Xenograft Model Antitumor Assays
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