Delivery of oligonucleotides with lipid nanoparticles

Since their inception in the 1980s, oligonucleotide-based (ON-based) therapeutics have been recognized as powerful tools that can treat a broad spectrum of diseases. The discoveries of novel regulatory methods of gene expression with diverse mechanisms of action are still driving the development of...

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Veröffentlicht in:	Advanced drug delivery reviews 2015-06, Vol.87, p.68-80
Hauptverfasser:	Wang, Yuhua, Miao, Lei, Satterlee, Andrew, Huang, Leaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Chemistry, Pharmaceutical Drug Carriers - chemistry Drug Compounding Drug Liberation Humans Immunotherapy - methods Lipid nanoparticles Lipids - chemistry Lipoplexes Liposome Liposomes Liver Diseases - drug therapy Liver Diseases - metabolism Lung Diseases - drug therapy Lung Diseases - metabolism Nanoparticles - chemistry Oligonucleotides Oligonucleotides - administration & dosage Oligonucleotides - pharmacokinetics Oligonucleotides - therapeutic use Surface Properties Systemic delivery
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