ADS-J1 inhibits semen-derived amyloid fibril formation and blocks fibril-mediated enhancement of HIV-1 infection

Semen-derived enhancer of viral infection (SEVI) is composed of amyloid fibrils that can greatly enhance HIV-1 infectivity. By its cationic property, SEVI promotes viral sexual transmission by facilitating the attachment and internalization of HIV-1 to target cells. Therefore, semen-derived amyloid...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-09, Vol.59 (9), p.5123-5134
Hauptverfasser:	Xun, Tianrong, Li, Wenjuan, Chen, Jinquan, Yu, Fei, Xu, Wei, Wang, Qian, Yu, Ruizhe, Li, Xiaojuan, Zhou, Xuefeng, Lu, Lu, Jiang, Shibo, Li, Lin, Tan, Suiyi, Liu, Shuwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Amyloid - metabolism Amyloid - ultrastructure Anti-HIV Agents Anti-HIV Agents - chemistry Anti-HIV Agents - metabolism Anti-HIV Agents - therapeutic use Antiviral Agents HIV Infections HIV Infections - drug therapy Humans Microscopy, Electron, Transmission Naphthalenesulfonates Naphthalenesulfonates - chemistry Naphthalenesulfonates - metabolism Naphthalenesulfonates - therapeutic use Semen Semen - chemistry Triazines Triazines - chemistry Triazines - metabolism Triazines - therapeutic use
Online-Zugang:	Volltext
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