Monoselective o‑C–H Functionalizations of Mandelic Acid and α‑Phenylglycine

Pd-catalyzed C–H functionalization of mandelic acid and α-phenylglycine is reported. We have developed different protocols for the arylation, iodination, acetoxylation, and olefination of these substrates based on two different (Pd­(II)/Pd­(IV) and Pd­(II)/Pd(0)) catalytic cycles. Four crucial featu...

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Veröffentlicht in:	Journal of the American Chemical Society 2015-08, Vol.137 (31), p.9877-9884
Hauptverfasser:	Dastbaravardeh, Navid, Toba, Tetsuya, Farmer, Marcus E, Yu, Jin-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	acetates Alkenes - chemistry carbamates Carbon - chemistry Catalysis Glycine - analogs & derivatives Glycine - chemistry Halogenation Hydrogen - chemistry iodination mandelic acid Mandelic Acids - chemistry Palladium - chemistry standard operating procedures Substrate Specificity
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