ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes
ω -3 PUFAs and polyphenols have multiple effects on inflammation in vivo and in vitro. The effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and resveratrol (RV) were investigated in LPS-stimulated peripheral blood leukocytes (PBLs) (i.e., acute inflammation) and IL-1β activated hu...
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| description | ω -3 PUFAs and polyphenols have multiple effects on inflammation in vivo and in vitro. The effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and resveratrol (RV) were investigated in LPS-stimulated peripheral blood leukocytes (PBLs) (i.e., acute inflammation) and IL-1β activated human chondrocytes (i.e., chronic inflammation). Inflammatory mediators including chemokines, cytokines, interleukins, and PGE2 were measured by multiplex analysis and gene expression was quantified by RT-PCR. In PBLs, RV decreased the secretion of PGE2, CCL5/RANTES, and CXCL8/IL-8 but increased IL-1β, IL-6, and IL-10. In contrast to RV, ω-3 PUFAs augmented the production of PGE2 and CXCL8/IL-8. EPA and DHA similarly affected the pattern of inflammatory mediators. Combination of RV and ω-3 PUFAs exerted synergistic effects on CCL5/RANTES and had additive effects on IL-6 or CXCL8/IL-8. Both ω-3 PUFAs and RV reduced catabolic gene expression (e.g., MMPs, ADAMTS-4, IL-1β, and IL-6) in activated chondrocytes. The data suggest that ω-3 PUFAs and RV differ in the regulation of acute inflammation of peripheral blood leukocytes but have common properties in modulating features related to chronic inflammation of chondrocytes. |
| doi_str_mv | 10.1155/2015/535189 |
| format | Article |
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The effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and resveratrol (RV) were investigated in LPS-stimulated peripheral blood leukocytes (PBLs) (i.e., acute inflammation) and IL-1β activated human chondrocytes (i.e., chronic inflammation). Inflammatory mediators including chemokines, cytokines, interleukins, and PGE2 were measured by multiplex analysis and gene expression was quantified by RT-PCR. In PBLs, RV decreased the secretion of PGE2, CCL5/RANTES, and CXCL8/IL-8 but increased IL-1β, IL-6, and IL-10. In contrast to RV, ω-3 PUFAs augmented the production of PGE2 and CXCL8/IL-8. EPA and DHA similarly affected the pattern of inflammatory mediators. Combination of RV and ω-3 PUFAs exerted synergistic effects on CCL5/RANTES and had additive effects on IL-6 or CXCL8/IL-8. Both ω-3 PUFAs and RV reduced catabolic gene expression (e.g., MMPs, ADAMTS-4, IL-1β, and IL-6) in activated chondrocytes. The data suggest that ω-3 PUFAs and RV differ in the regulation of acute inflammation of peripheral blood leukocytes but have common properties in modulating features related to chronic inflammation of chondrocytes.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/535189</identifier><identifier>PMID: 26301248</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acute Disease ; Chondrocytes - drug effects ; Chondrocytes - metabolism ; Chondrocytes - pathology ; Chronic Disease ; Docosahexaenoic Acids - administration & dosage ; Eicosapentaenoic Acid - administration & dosage ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - metabolism ; Gene Expression Regulation - drug effects ; Humans ; Inflammation - chemically induced ; Inflammation - diet therapy ; Inflammation - genetics ; Inflammation - pathology ; Interleukin-10 - biosynthesis ; Interleukin-6 - biosynthesis ; Interleukin-8 - biosynthesis ; Leukocytes - drug effects ; Lipopolysaccharides - toxicity ; Resveratrol ; Stilbenes - administration & dosage ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>BioMed research international, 2015, Vol.2015 (2015), p.1-11</ispartof><rights>Copyright © 2015 Joseph Schwager et al.</rights><rights>Copyright © 2015 Joseph Schwager et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3879-3b65df054b749a3ee936a544548fcbc0c9cbc978df9ac8939007eb69a3b797c03</citedby><cites>FETCH-LOGICAL-c3879-3b65df054b749a3ee936a544548fcbc0c9cbc978df9ac8939007eb69a3b797c03</cites><orcidid>0000-0002-7091-6896 ; 0000-0002-6174-6063</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537711/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537711/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26301248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Su, Hui-Min</contributor><creatorcontrib>Salem, Norman</creatorcontrib><creatorcontrib>Riegger, Christoph</creatorcontrib><creatorcontrib>Richard, Nathalie</creatorcontrib><creatorcontrib>Schwager, Joseph</creatorcontrib><title>ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>ω -3 PUFAs and polyphenols have multiple effects on inflammation in vivo and in vitro. The effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and resveratrol (RV) were investigated in LPS-stimulated peripheral blood leukocytes (PBLs) (i.e., acute inflammation) and IL-1β activated human chondrocytes (i.e., chronic inflammation). Inflammatory mediators including chemokines, cytokines, interleukins, and PGE2 were measured by multiplex analysis and gene expression was quantified by RT-PCR. In PBLs, RV decreased the secretion of PGE2, CCL5/RANTES, and CXCL8/IL-8 but increased IL-1β, IL-6, and IL-10. In contrast to RV, ω-3 PUFAs augmented the production of PGE2 and CXCL8/IL-8. EPA and DHA similarly affected the pattern of inflammatory mediators. Combination of RV and ω-3 PUFAs exerted synergistic effects on CCL5/RANTES and had additive effects on IL-6 or CXCL8/IL-8. Both ω-3 PUFAs and RV reduced catabolic gene expression (e.g., MMPs, ADAMTS-4, IL-1β, and IL-6) in activated chondrocytes. The data suggest that ω-3 PUFAs and RV differ in the regulation of acute inflammation of peripheral blood leukocytes but have common properties in modulating features related to chronic inflammation of chondrocytes.</description><subject>Acute Disease</subject><subject>Chondrocytes - drug effects</subject><subject>Chondrocytes - metabolism</subject><subject>Chondrocytes - pathology</subject><subject>Chronic Disease</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Eicosapentaenoic Acid - administration & dosage</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - diet therapy</subject><subject>Inflammation - genetics</subject><subject>Inflammation - pathology</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Leukocytes - drug effects</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Resveratrol</subject><subject>Stilbenes - administration & dosage</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqN0U9LHDEYBvBQKirqyXuZY6mMJpv_l8KyahUUF6nQW8hk3nSnzExsMrOyH6Gfrl-pWVYXe9sckkB-PLzhQeiU4HNCOL-YYMIvOOVE6Q_ocEIJKwVh5OP2TukBOknpF85LEYG12EcHE0ExmTB1iH78_VPSYv50PU2F7eviEdISoh1iaIvLxnuI0A_tqrgP9djaAYqpG_O-prNFDH3jitvet7br7BDiqpjH4CAlSMdoz9s2wcnreYSerq--z27Ku4dvt7PpXemokrqkleC1x5xVkmlLATQVljPGmfKuctjpvGupaq-tU5pqjCVUItNKaukwPUJfN7nPY9VB7fK40bbmOTadjSsTbGP-f-mbhfkZloZxKiUhOeDza0AMv0dIg-ma5KBtbQ9hTIZIrInQQvBdqOBSCqIyPdtQF0NKEfx2IoLNujmzbs5smsv60_tPbO1bTxl82YBF09f2pdktDTIBb99hzhXn9B815qpa</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Salem, Norman</creator><creator>Riegger, Christoph</creator><creator>Richard, Nathalie</creator><creator>Schwager, Joseph</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7091-6896</orcidid><orcidid>https://orcid.org/0000-0002-6174-6063</orcidid></search><sort><creationdate>2015</creationdate><title>ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes</title><author>Salem, Norman ; Riegger, Christoph ; Richard, Nathalie ; Schwager, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3879-3b65df054b749a3ee936a544548fcbc0c9cbc978df9ac8939007eb69a3b797c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute Disease</topic><topic>Chondrocytes - drug effects</topic><topic>Chondrocytes - metabolism</topic><topic>Chondrocytes - pathology</topic><topic>Chronic Disease</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Eicosapentaenoic Acid - administration & dosage</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Humans</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - diet therapy</topic><topic>Inflammation - genetics</topic><topic>Inflammation - pathology</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Leukocytes - drug effects</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Resveratrol</topic><topic>Stilbenes - administration & dosage</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salem, Norman</creatorcontrib><creatorcontrib>Riegger, Christoph</creatorcontrib><creatorcontrib>Richard, Nathalie</creatorcontrib><creatorcontrib>Schwager, Joseph</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salem, Norman</au><au>Riegger, Christoph</au><au>Richard, Nathalie</au><au>Schwager, Joseph</au><au>Su, Hui-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2015</date><risdate>2015</risdate><volume>2015</volume><issue>2015</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>ω -3 PUFAs and polyphenols have multiple effects on inflammation in vivo and in vitro. The effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and resveratrol (RV) were investigated in LPS-stimulated peripheral blood leukocytes (PBLs) (i.e., acute inflammation) and IL-1β activated human chondrocytes (i.e., chronic inflammation). Inflammatory mediators including chemokines, cytokines, interleukins, and PGE2 were measured by multiplex analysis and gene expression was quantified by RT-PCR. In PBLs, RV decreased the secretion of PGE2, CCL5/RANTES, and CXCL8/IL-8 but increased IL-1β, IL-6, and IL-10. In contrast to RV, ω-3 PUFAs augmented the production of PGE2 and CXCL8/IL-8. EPA and DHA similarly affected the pattern of inflammatory mediators. Combination of RV and ω-3 PUFAs exerted synergistic effects on CCL5/RANTES and had additive effects on IL-6 or CXCL8/IL-8. Both ω-3 PUFAs and RV reduced catabolic gene expression (e.g., MMPs, ADAMTS-4, IL-1β, and IL-6) in activated chondrocytes. The data suggest that ω-3 PUFAs and RV differ in the regulation of acute inflammation of peripheral blood leukocytes but have common properties in modulating features related to chronic inflammation of chondrocytes.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26301248</pmid><doi>10.1155/2015/535189</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7091-6896</orcidid><orcidid>https://orcid.org/0000-0002-6174-6063</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Chronic Disease Docosahexaenoic Acids - administration & dosage Eicosapentaenoic Acid - administration & dosage Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - metabolism Gene Expression Regulation - drug effects Humans Inflammation - chemically induced Inflammation - diet therapy Inflammation - genetics Inflammation - pathology Interleukin-10 - biosynthesis Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis Leukocytes - drug effects Lipopolysaccharides - toxicity Resveratrol Stilbenes - administration & dosage Tumor Necrosis Factor-alpha - biosynthesis |
| title | ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes |
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